SCHEMBL4180715

SCHEMBL4180715

NCC(Oc1ccc(F)cc1)C(=O)O

nearest known ligand 0.64

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PPARG P37231 18/20 0.64
PPARA Q07869 16/20 0.64
ALDH1A1 P00352 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL18321310 0.98 PPARG (0.62) PPARGPPARAALDH1A1
SCHEMBL4187184 0.84 LDHA (0.61) PPARGPPARA
SCHEMBL4170587 0.83 PPARG (0.57) PPARGPPARA
SCHEMBL4173522 0.82 PPARG (0.68) PPARGPPARA
SCHEMBL4183099 0.82 PPARG (0.46) PPARGPPARA
SCHEMBL8935658 0.82 PPARG (0.64) PPARGPPARAALDH1A1
SCHEMBL8935654 0.82 PPARG (0.64) PPARGPPARAALDH1A1
SCHEMBL2106689 0.79 PPARG (0.63) PPARGPPARAALDH1A1
SCHEMBL28745487 0.79 PPARG (0.63) PPARGPPARAALDH1A1
SCHEMBL8864038 0.78 CTRC (0.57) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090227680-A1 Amino Acid Derivatives PFIZER, INC. (US) 2009-09-10 US claimed
EP-1951655-A2 AMINO ACID DERIVATIVES Pfizer Limited (GB) 2008-08-06 EP claimed
WO-2007057767-A2 AMINO ACID DERIVATIVES PFIZER LIMITED (GB) 2007-05-24 WO claimed
US-11730714-B2 Compounds for the treatment of neuromuscular disorders NMD PHARMA A/S (DK) 2023-08-22 US disclosed
US-11730714-B2 Compounds for the treatment of neuromuscular disorders NMD PHARMA A/S (DK) 2023-08-22 US disclosed
US-11147788-B2 Compounds for the treatment of neuromuscular disorders NMD PHARMA A/S (DK) 2021-10-19 US disclosed
EP-3307262-B1 COMPOUNDS FOR USE IN TREATING NEUROMUSCULAR DISORDERS NMD PHARMA AS (DK) 2021-05-19 EP disclosed
US-10934244-B2 Compounds for use in treating neuromuscular disorders NMD PHARMA A/S (DK) 2021-03-02 US disclosed
US-10385028-B2 Compounds for the treatment of neuromuscular disorders NMD PHARMA A/S (DK) 2019-08-20 US disclosed
US-20190183863-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA A/S (DK) 2019-06-20 US disclosed
US-20190183833-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA APS 2019-06-20 US disclosed
US-20190183812-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA A/S (DK) 2019-06-20 US disclosed
US-20190185437-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA APS (DK) 2019-06-20 US disclosed
US-20190183834-A1 Compounds For The Treatment Of Neuromuscular Disorders NMD PHARMA A/S (DK) 2019-06-20 US disclosed
US-20180099920-A1 COMPOUNDS FOR USE IN TREATING NEUROMUSCULAR DISORDERS NMD PHARMA APS (DK) 2018-04-12 US disclosed
US-20180099920-A1 COMPOUNDS FOR USE IN TREATING NEUROMUSCULAR DISORDERS NMD PHARMA APS (DK) 2018-04-12 US disclosed
WO-2016202341-A1 COMPOUNDS FOR USE IN TREATING NEUROMUSCULAR DISORDERS NMD PHARMA APS (DK) 2016-12-22 WO disclosed
US-20090227680-A1 Amino Acid Derivatives PFIZER, INC. (US) 2009-09-10 US disclosed
EP-1951655-A2 AMINO ACID DERIVATIVES Pfizer Limited (GB) 2008-08-06 EP disclosed
WO-2007057767-A2 AMINO ACID DERIVATIVES PFIZER LIMITED (GB) 2007-05-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11730714-B2 Compounds for the treatment of neuromuscular disorders RYR1, CACNB1, RYR2 PPARG 3332/4885PPARA 3247/4885ALDH1A1 1343/4885
US-20090227680-A1 Amino Acid Derivatives OPRL1, OPRK1, AVPR1A PPARG 2322/4885PPARA 1589/4885ALDH1A1 851/4885
US-10934244-B2 Compounds for use in treating neuromuscular disorders CPT1B, CLCN2, TNNC1 PPARG 2105/4885PPARA 2774/4885ALDH1A1 1498/4885
US-20190183834-A1 Compounds For The Treatment Of Neuromuscular Disorders RYR1, CACNB1, RYR2 PPARG 3332/4885PPARA 3247/4885ALDH1A1 1343/4885
US-20180099920-A1 COMPOUNDS FOR USE IN TREATING NEUROMUSCULAR DISORDERS CPT1B, CLCN2, TNNC1 PPARG 2105/4885PPARA 2774/4885ALDH1A1 1498/4885
US-20190183812-A1 Compounds For The Treatment Of Neuromuscular Disorders RYR1, CACNB1, RYR2 PPARG 3332/4885PPARA 3247/4885ALDH1A1 1343/4885
US-11147788-B2 Compounds for the treatment of neuromuscular disorders RYR1, CACNB1, RYR2 PPARG 3332/4885PPARA 3247/4885ALDH1A1 1343/4885
US-10385028-B2 Compounds for the treatment of neuromuscular disorders RYR1, CACNB1, RYR2 PPARG 3332/4885PPARA 3247/4885ALDH1A1 1343/4885
US-20190183863-A1 Compounds For The Treatment Of Neuromuscular Disorders RYR1, CACNB1, RYR2 PPARG 3332/4885PPARA 3247/4885ALDH1A1 1343/4885
US-20190185437-A1 Compounds For The Treatment Of Neuromuscular Disorders CLCN2, SCN1B, CACNB1 PPARG 3152/4885PPARA 3651/4885ALDH1A1 1891/4885
US-20190183833-A1 Compounds For The Treatment Of Neuromuscular Disorders RYR1, CACNB1, RYR2 PPARG 3332/4885PPARA 3247/4885ALDH1A1 1343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.