SCHEMBL418362

SCHEMBL418362

O=[N+]([O-])c1c(F)cccc1Br

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 4/20 0.43
ALDH1A1 P00352 3/20 0.43
PMM2 O15305 1/20 0.40
MPI P34949 1/20 0.40
TSHR P16473 2/20 0.38
GPR35 Q9HC97 2/20 0.38
LMNA P02545 2/20 0.37
MAPT P10636 3/20 0.37
PKM P14618 1/20 0.37
VCP P55072 1/20 0.36
MAPK1 P28482 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CYP3A4 P08684 1/20 0.35
ATM Q13315 1/20 0.35
PDE7A Q13946 2/20 0.35
PDE7B Q9NP56 2/20 0.35
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
HPGD P15428 1/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29532105 1.00 TDP1 (0.43) TDP1ALDH1A1PMM2MPITSHR
SCHEMBL9452627 0.84 ALDH1A1 (0.52) TDP1ALDH1A1PMM2MPITSHR
SCHEMBL240574 0.84 TDP1 (0.52) TDP1ALDH1A1TSHRGPR35LMNA
SCHEMBL1161245 0.79 TDP1 (0.43) TDP1ALDH1A1TSHRGPR35LMNA
SCHEMBL30267557 0.79 TDP1 (0.43) TDP1ALDH1A1TSHRGPR35LMNA
SCHEMBL29557370 0.77 GPR35 (0.59) TDP1ALDH1A1TSHRGPR35MAPT
SCHEMBL2843518 0.77 TDP1 (0.45) TDP1ALDH1A1TSHRGPR35LMNA
SCHEMBL1249766 0.77 TSHR (0.59) TDP1ALDH1A1PMM2MPITSHR
SCHEMBL1056952 0.77 TDP1 (0.45) TDP1ALDH1A1PMM2MPITSHR
SCHEMBL98247 0.77 GPR35 (0.59) TDP1ALDH1A1TSHRGPR35MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 291 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117645603-A P300 bromodomain inhibitor, pharmaceutical composition and application thereof 复旦大学 2024-03-05 CN claimed
CN-110305058-A A kind of 4- bromine carbazole preparation method 安徽秀朗新材料科技有限公司 2019-10-08 CN claimed
CN-108126656-A For the modified activated carbon absorbent of benzene in Adsorption wastewater from chemical industry 北京益清源环保科技有限公司 2018-06-08 CN claimed
US-20260150574-A1 COMPOSITION FOR ORGANIC OPTOELECTRONIC DIODE, ORGANIC OPTOELECTRONIC DIODE, AND DISPLAY DEVICE SAMSUNG SDI CO., LTD. (KR) 2026-05-28 US disclosed
US-12528833-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2026-01-20 US disclosed
US-12509628-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2025-12-30 US disclosed
US-20250381187-A1 KRAS G12C INHIBITORS AND METHODS OF USING THE SAME AMGEN INC. (US) 2025-12-18 US disclosed
US-20250368667-A1 USP1 INHIBITOR SHANGHAI QILU PHARMACEUTICAL RES AND DEVELOPMENT CENTRE LTD (CN) 2025-12-04 US disclosed
US-20250361210-A1 3,4-DIHYDROQUINOLIN-2(1H)-ONE COMPOUND KISSEI PHARMACEUTICAL CO., LTD. (JP) 2025-11-27 US disclosed
US-20250354060-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2025-11-20 US disclosed
US-20250351719-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2025-11-13 US disclosed
WO-2007135527-A2 BENZIMIDAZOLYL COMPOUNDS PFIZER PRODUCTS INC. (US) 2007-11-29 WO disclosed
WO-2007006677-A1 BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 F. HOFFMANN-LA ROCHE AG (CH) 2007-01-18 WO disclosed
WO-2007006677-A1 BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 F. HOFFMANN-LA ROCHE AG (CH) 2007-01-18 WO disclosed
US-20070015744-A1 Benzimidazolone and dihydroindolone derivatives and uses thereof ROCHE PALO ALTO LLC 2007-01-18 US disclosed
US-20070015744-A1 Benzimidazolone and dihydroindolone derivatives and uses thereof ROCHE PALO ALTO LLC 2007-01-18 US disclosed
US-20070015744-A1 Benzimidazolone and dihydroindolone derivatives and uses thereof ROCHE PALO ALTO LLC 2007-01-18 US disclosed
EP-0270964-B1 PROCESS FOR OBTAINING SUBSTITUTED FLUOROBENZENES BAYER AG (DE) 1992-07-08 EP disclosed
US-4868347-A SOLVENT EXTRACTION BAYER AKTIENGESELLSCHAFT (DE) 1989-09-19 US disclosed
EP-0270964-A2 Process for obtaining substituted fluorobenzenes BAYER AG (DE) 1988-06-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12509628-B2 Organic electroluminescent materials and devices LBR, OXSR1, GLRA1 TDP1 4586/4885ALDH1A1 2062/4885PMM2 4749/4885
US-20070015744-A1 Benzimidazolone and dihydroindolone derivatives and uses thereof RECQL, AR, DHX35 TDP1 2109/4885ALDH1A1 319/4885PMM2 3878/4885
US-20250351719-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES OCIAD1, OCIAD2, PDCD2L TDP1 2976/4885ALDH1A1 855/4885PMM2 1666/4885
US-20250368667-A1 USP1 INHIBITOR USP1, USP2, USP28 TDP1 1694/4885ALDH1A1 644/4885PMM2 3197/4885
US-20250381187-A1 KRAS G12C INHIBITORS AND METHODS OF USING THE SAME KRAS, NRAS, HRAS TDP1 3096/4885ALDH1A1 4162/4885PMM2 419/4885
US-20250361210-A1 3,4-DIHYDROQUINOLIN-2(1H)-ONE COMPOUND TSHR, TRHR, GHSR TDP1 2580/4885ALDH1A1 1515/4885PMM2 4486/4885
US-20260150574-A1 COMPOSITION FOR ORGANIC OPTOELECTRONIC DIODE, ORGANIC OPTOELECTRONIC DIODE, AND DISPLAY DEVICE OXER1, OR10J3, OPRD1 TDP1 4700/4885ALDH1A1 450/4885PMM2 4759/4885
US-12528833-B2 Organic electroluminescent materials and devices LBR, CHRM1, OPRD1 TDP1 3987/4885ALDH1A1 2117/4885PMM2 4082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.