Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.35 |
| ▸ | NMT1 | P30419 | 3/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4181434 | 0.99 | PIM1 (0.42) | PIM1KHKBACE1SLC6A4ITGB3 | |
| SCHEMBL4184390 | 0.82 | FAAH (0.36) | — | |
| SCHEMBL4184892 | 0.78 | GPR119 (0.45) | — | |
| SCHEMBL13927918 | 0.78 | HTR1A (0.45) | PIM1KHKBACE1SLC6A4NMT1 | |
| Hydrochloric Acid SCHEMBL4197686 | 0.75 | KHK (0.35) | PIM1KHKSLC6A4ITGB3ITGA2B | |
| SCHEMBL16519554 | 0.73 | ITGB3 (0.44) | KHKSLC6A4ITGB3ITGA2B | |
| SCHEMBL5783785 | 0.70 | TAAR1 (0.53) | SLC6A4 | |
| SCHEMBL13927875 | 0.68 | PARP1 (0.58) | SLC6A4 | |
| SCHEMBL23841931 | 0.68 | CRBN (0.40) | — | |
| SCHEMBL9468213 | 0.67 | CASP3 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042874-A1 | ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042874-A1 | ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | HTR5A, CRH, CYP17A1 | PIM1 4864/4885KHK 2693/4885BACE1 2447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.