Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SMAD3 | P84022 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9860607 | 0.76 | ALDH1A1 (0.47) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 | |
| SCHEMBL1153101 | 0.72 | PDE4A (0.35) | — | |
| SCHEMBL11698952 | 0.71 | SHBG (0.39) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL28727085 | 0.71 | KMT2A (0.41) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9860501 | 0.69 | CYP3A4 (0.58) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 | |
| SCHEMBL352250 | 0.68 | CYP3A4 (0.53) | CYP3A4CYP2D6CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1154551 | 0.68 | MAPT (0.41) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 | |
| SCHEMBL7284764 | 0.68 | KDM4E (0.43) | CYP2C9HSD17B10 | |
| SCHEMBL9151513 | 0.68 | CYP3A4 (0.37) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 | |
| SCHEMBL9860674 | 0.67 | P4HB (0.52) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | UNIVERSITY OF NEBRASKA - LINCOLN | 2015-01-29 | — | — | US | disclosed |
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | UNIVERSITY OF NEBRASKA - LINCOLN | 2015-01-29 | — | — | US | disclosed |
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | UNIVERSITY OF NEBRASKA - LINCOLN | 2015-01-29 | — | — | US | disclosed |
| US-8859614-B2 | Analogues of (−)-picropodophyllin, synthesis and uses thereof | University of Nebraska—Lincoln (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859614-B2 | Analogues of (−)-picropodophyllin, synthesis and uses thereof | University of Nebraska—Lincoln (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859614-B2 | Analogues of (−)-picropodophyllin, synthesis and uses thereof | University of Nebraska—Lincoln (US) | 2014-10-14 | — | — | US | disclosed |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2009-10-29 | — | — | US | disclosed |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2009-10-29 | — | — | US | disclosed |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2009-10-29 | — | — | US | disclosed |
| WO-2009100349-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009100349-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | PPOX, HCCS, DHPS | CYP3A4 520/4885CYP2D6 326/4885CYP1A2 264/4885 |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | PPOX, HCCS, DHPS | CYP3A4 566/4885CYP2D6 302/4885CYP1A2 248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.