Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10483567 | 0.80 | ALDH1A1 (0.43) | ALDH1A1GAAMAPTPKMGLA | |
| SCHEMBL3464366 | 0.79 | ALDH1A1 (0.50) | ALDH1A1GAAMAPTPKMGLA | |
| SCHEMBL4193348 | 0.76 | CYP3A4 (0.40) | ALOX15CYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11095079 | 0.75 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTPKMGLA | |
| SCHEMBL500009 | 0.72 | APLNR (0.32) | — | |
| SCHEMBL31039446 | 0.72 | APLNR (0.32) | — | |
| SCHEMBL1751672 | 0.72 | AHR (0.53) | ALDH1A1GAAMAPTPKMCYP3A4 | |
| SCHEMBL11384732 | 0.71 | ALDH1A1 (0.44) | ALDH1A1GAAMAPTPKMGLA | |
| SCHEMBL5997064 | 0.71 | LMNA (0.55) | ALDH1A1MAPTPKMHPGDPOLB | |
| SCHEMBL11862920 | 0.69 | P4HB (0.45) | ALDH1A1GAAMAPTGLACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | UNIVERSITY OF NEBRASKA - LINCOLN | 2015-01-29 | — | — | US | disclosed |
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | UNIVERSITY OF NEBRASKA - LINCOLN | 2015-01-29 | — | — | US | disclosed |
| US-8859614-B2 | Analogues of (−)-picropodophyllin, synthesis and uses thereof | University of Nebraska—Lincoln (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859614-B2 | Analogues of (−)-picropodophyllin, synthesis and uses thereof | University of Nebraska—Lincoln (US) | 2014-10-14 | — | — | US | disclosed |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2009-10-29 | — | — | US | disclosed |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2009-10-29 | — | — | US | disclosed |
| US-5070103-A | ANTILIPEMIC AGENTS, ARTERIOSCLEROSIS | TANABE SEIYAKU CO., LTD. (JP) | 1991-12-03 | — | — | US | disclosed |
| EP-0188248-B1 | NAPHTHALENE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | TANABE SEIYAKU CO., LTD. (JP) | 1990-07-11 | — | — | EP | disclosed |
| US-4897418-A | ANTILIPEMIC AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1990-01-30 | — | — | US | disclosed |
| US-4771072-A | HYPOLIPIDEMIC ACTIVITY | TANABE SEIYAKU CO., LTD. (JP) | 1988-09-13 | — | — | US | disclosed |
| EP-0188248-A2 | Naphthalene derivatives, process for the preparation thereof and pharmaceutical composition containing same | TANABE SEIYAKU CO., LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | PPOX, HCCS, DHPS | ALDH1A1 2192/4885GAA 1960/4885MAPT 4393/4885 |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | PPOX, HCCS, DHPS | ALDH1A1 2006/4885GAA 2025/4885MAPT 4344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.