Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.70 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | CTSV | O60911 | 2/20 | 0.61 |
| ▸ | CTSL | P07711 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | MYC | P01106 | 1/20 | 0.55 |
| ▸ | MAX | P61244 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ASPH | Q12797 | 1/20 | 0.54 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.54 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4214475 | 1.00 | CRHBP (0.70) | CRHBPCRHR2MAPTCTSVCTSL | |
| SCHEMBL9834480 | 1.00 | CRHBP (0.70) | CRHBPCRHR2MAPTCTSVCTSL | |
| SCHEMBL9838079 | 0.89 | MAPT (0.58) | CRHBPCRHR2MAPTCTSVCTSL | |
| SCHEMBL9835884 | 0.87 | CTSV (0.67) | CRHBPCRHR2MAPTCTSVCTSL | |
| SCHEMBL9837463 | 0.85 | MPO (0.56) | CRHBPCRHR2MAPTCTSVCTSL | |
| SCHEMBL17434401 | 0.85 | MAPT (0.70) | MAPTCTSVCTSLKMT2AMEN1 | |
| SCHEMBL9837491 | 0.84 | KMT2A (0.58) | CRHBPCRHR2MAPTCTSVCTSL | |
| SCHEMBL3462623 | 0.84 | MAPT (0.58) | CRHBPCRHR2MAPTCTSVCTSL | |
| SCHEMBL9837317 | 0.83 | ANO1 (0.57) | CRHBPCRHR2MAPTCTSVCTSL | |
| SCHEMBL9837846 | 0.82 | CTSV (0.56) | CRHBPCRHR2MAPTCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | MYRIAD GENETICS, INCORPORATED (US) | 2009-06-18 | — | — | US | disclosed |
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | MYRIAD GENETICS, INCORPORATED (US) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | APP, PSEN2, PSEN1 | CRHBP 3480/4885CRHR2 2433/4885MAPT 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.