Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4239107 | 0.84 | TSHR (0.63) | TSHRALDH1A1NPC1POLBKMT2A | |
| SCHEMBL8587599 | 0.84 | TSHR (0.44) | TSHRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL10784078 | 0.80 | ALDH1A1 (0.67) | TSHRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL4629654 | 0.80 | CYP3A4 (0.67) | TSHRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL10712239 | 0.80 | KMT2A (0.41) | TSHRALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL789770 | 0.80 | KMT2A (0.41) | TSHRALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL7301332 | 0.79 | THRB (0.50) | ALDH1A1KDM4EPOLBKMT2AHPGD | |
| SCHEMBL4240186 | 0.79 | TDP1 (0.64) | TSHRALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL2148841 | 0.78 | LMNA (0.57) | TSHRALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL27986491 | 0.77 | TSHR (0.61) | TSHRALDH1A1NPC1CYP3A4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186859-A1 | DIAZENIUMDIOLATED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, COMPOSITIONS THEREOF, AND RELATED METHODS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SEC., DEPT. OF HEALTH AND HUMAN SERVICES (MD) | 2009-07-23 | — | — | US | disclosed |
| EP-2010486-A2 | DIAZENIUMDIOLATED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, COMPOSITIONS THEREOF, AND RELATED METHODS | The Government Of The United States Of America As Representative National Institutes of Health (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007127725-A2 | DIAZENIUMDIOLATED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, COMPOSITIONS THEREOF, AND RELATED METHODS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186859-A1 | DIAZENIUMDIOLATED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, COMPOSITIONS THEREOF, AND RELATED METHODS | NOS2, NOS1, NOS3 | TSHR 2338/4885ALDH1A1 380/4885NPC1 1452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.