SCHEMBL422886

SCHEMBL422886

Cn1ncc2ccc(Br)cc21

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMO O15229 2/20 0.55
EGFR P00533 1/20 0.46
IRAK4 Q9NWZ3 2/20 0.46
NOTUM Q6P988 1/20 0.44
ERCC1 P07992 1/20 0.43
ERCC4 Q92889 1/20 0.43
ESRRG P62508 1/20 0.40
CDK8 P49336 2/20 0.40
PDE1C Q14123 1/20 0.40
CYP11B2 P19099 1/20 0.39
MPO P05164 1/20 0.39
FGFR1 P11362 1/20 0.38
FGFR4 P22455 1/20 0.38
CYP1A2 P05177 1/20 0.38
GRM4 Q14833 1/20 0.38
HTR2A P28223 1/20 0.38
HTR2C P28335 1/20 0.38
HTR2B P41595 1/20 0.38
VNN1 O95497 1/20 0.37
CCNC P24863 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29427078 1.00 KMO (0.55) KMOEGFRIRAK4NOTUMERCC1
SCHEMBL31731004 0.87 KMO (0.48) KMOEGFRIRAK4NOTUMERCC1
SCHEMBL11794 0.84 EGFR (0.46) KMOEGFRPDE1CCYP11B2CYP1A2
SCHEMBL6181444 0.79 KMO (0.59) KMOIRAK4NOTUMFGFR1FGFR4
SCHEMBL30381343 0.79 KMO (0.59) KMOIRAK4NOTUMFGFR1FGFR4
SCHEMBL17673818 0.78 KMO (0.66) KMOEGFRIRAK4FGFR1FGFR4
SCHEMBL13106103 0.78 PTK2 (0.54) MPOCYP1A2GRM4VNN1
SCHEMBL27261035 0.78 EGFR (0.43) KMOEGFRIRAK4ESRRGHTR2A
SCHEMBL29901474 0.78 KMO (0.57) KMONOTUMERCC1ERCC4ESRRG
SCHEMBL425168 0.78 KMO (0.57) KMONOTUMERCC1ERCC4ESRRG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 292 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12258318-B2 Synthesis method for 1-methyl-1H-indazole-6-carboxylic acid ACCELA CHEMBIO CO., LTD. (CN) 2025-03-25 US claimed
US-20220235010-A1 SYNTHESIS METHOD FOR 1-METHYL-1H-INDAZOLE-6-CARBOXYLIC ACID ACCELA CHEMBIO CO., LTD. (CN) 2022-07-28 US claimed
WO-2020253533-A1 SYNTHESIS METHOD FOR 1-METHYL-1H-INDAZOLE-6-CARBOXYLIC ACID 韶远科技(上海)有限公司 2020-12-24 WO claimed
US-20260125400-A1 TYK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-05-07 US disclosed
EP-4736854-A2 HETEROCYCLIC COMPOUNDS AS MODULATORS OF BCL6 AS LIGAND DIRECTED DEGRADERS Bristol-Myers Squibb Company (US) 2026-05-06 EP disclosed
US-20260070884-A1 Inhibitors of Dihydroceramide Desaturase for Treating Disease CENTAURUS THERAPEUTICS (US) 2026-03-12 US disclosed
US-12570607-B2 Compound as cyclin-dependent kinase 9 inhibitor and use thereof CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) 2026-03-10 US disclosed
US-20260055062-A1 HETEROCYCLIC INHIBITORS OF MCT4 Vettore, LLC 2026-02-26 US disclosed
EP-4514473-B1 HETEROCYCLIC COMPOUNDS AS MODULATORS OF BCL6 AS LIGAND DIRECTED DEGRADERS BRISTOL MYERS SQUIBB CO (US) 2026-02-18 EP disclosed
US-20260008760-A1 DIPEPTIDYL PEPTIDASE 1 INHIBITORS AND USES THEREOF INSMED INCORPORATED 2026-01-08 US disclosed
EP-4387963-B1 PHENYL- AND PYRIDOPYRAZOLE DERIVATIVES AS INHIBITORS OF DDR1 REDX PHARMA LTD (GB) 2025-12-24 EP disclosed
US-20070197564-A1 Compounds for the treatment of inflammatory disorders SCHERING CORPORATION 2007-08-23 US disclosed
US-20070197564-A1 Compounds for the treatment of inflammatory disorders SCHERING CORPORATION 2007-08-23 US disclosed
US-20070197564-A1 Compounds for the treatment of inflammatory disorders SCHERING CORPORATION 2007-08-23 US disclosed
WO-2007084451-A1 HYDANTOIN DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISORDERS SCHERING CORPORATION (US) 2007-07-26 WO disclosed
CN-1863532-A Azaspiroalkane derivatives as metalloproteinase inhibitors INCYTE COPORATION (US) 2006-11-15 CN disclosed
US-6867320-B2 Substituted phenylalkanoic acid derivatives and use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2005-03-15 US disclosed
US-20040259896-A1 N-hydroxy-5-methyl-6-{[4-(3-methylphenyl)piperazin-1-yl]carbonyl}-5-azaspiro[2.5]octane-7-carboxamide for example; treating arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions INCYTE CORPORATION 2004-12-23 US disclosed
EP-1477472-A1 SUBSTITUTED PHENYLALKANOIC ACID DERIVATIVE AND USE THEREOF Asahi Kasei Pharma Corporation (JP) 2004-11-17 EP disclosed
US-20040044258-A1 Substituted phenylalkanoic acid derivatives and use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2004-03-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260125400-A1 TYK2 DEGRADERS AND USES THEREOF TYK2, CSNK2A1, CSNK2A2 KMO 64/4885EGFR 158/4885IRAK4 365/4885
US-20260070884-A1 Inhibitors of Dihydroceramide Desaturase for Treating Disease CERS2, DEGS1, CERT1 KMO 1686/4885EGFR 1670/4885IRAK4 3103/4885
US-12570607-B2 Compound as cyclin-dependent kinase 9 inhibitor and use thereof CDK9, CDK4, CDKL4 KMO 2243/4885EGFR 859/4885IRAK4 1385/4885
US-20260008760-A1 DIPEPTIDYL PEPTIDASE 1 INHIBITORS AND USES THEREOF DPP9, DPP7, DPP4 KMO 2575/4885EGFR 1496/4885IRAK4 1666/4885
US-20070197564-A1 Compounds for the treatment of inflammatory disorders ADAMTS1, ADAMTS13, ADAMTS7 KMO 1734/4885EGFR 1457/4885IRAK4 359/4885
US-20040044258-A1 Substituted phenylalkanoic acid derivatives and use thereof PTGER1, CYSLTR1, PTGS1 KMO 687/4885EGFR 3359/4885IRAK4 120/4885
US-20040259896-A1 N-hydroxy-5-methyl-6-{[4-(3-methylphenyl)piperazin-1-yl]carbonyl}-5-azaspiro[2.5]octane-7-carboxamide for example; treating arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions MMP9, MMP25, HDAC5 KMO 38/4885EGFR 1726/4885IRAK4 659/4885
US-20260055062-A1 HETEROCYCLIC INHIBITORS OF MCT4 SLC16A1, SLC16A3, SLC16A7 KMO 1040/4885EGFR 1378/4885IRAK4 404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.