Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 4/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10176167 | 0.80 | CYP11B2 (0.80) | CYP11B2CYP11B1NAMPTATMKIT | |
| SCHEMBL10175606 | 0.80 | CYP11B2 (0.60) | CYP11B2CYP11B1NAMPTATMKIT | |
| SCHEMBL10176218 | 0.80 | CYP11B2 (0.60) | CYP11B2CYP11B1NAMPTATMKIT | |
| SCHEMBL19763372 | 0.80 | CA1 (0.51) | HTTMEN1KMT2A | |
| SCHEMBL17883781 | 0.80 | PTGS2 (0.57) | CYP11B2CYP11B1NAMPTATMKIT | |
| SCHEMBL12407941 | 0.79 | MDM2 (0.49) | NAMPTATMTTKDHFR | |
| SCHEMBL17896670 | 0.79 | NAMPT (0.67) | CYP11B2CYP11B1NAMPTATMKIT | |
| SCHEMBL10175817 | 0.78 | RAD51 (0.60) | CYP11B2CYP11B1NAMPTATMKIT | |
| SCHEMBL1104859 | 0.78 | MEN1 (0.69) | CYP11B2CYP11B1ATMUSP2HTT | |
| SCHEMBL10175106 | 0.78 | ALDH1A1 (0.56) | CYP11B2CYP11B1NAMPTATMKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048252-A1 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-02-19 | — | — | US | disclosed |
| EP-1993536-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-11-26 | — | — | EP | disclosed |
| US-20070249599-A1 | Novel Chemical Compounds | DUFFY KEVIN J | 2007-10-25 | — | — | US | disclosed |
| WO-2007103755-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249599-A1 | Novel Chemical Compounds | HIPK3, HIPK1, HIPK4 | CYP11B2 4272/4885CYP11B1 4239/4885NAMPT 3218/4885 |
| US-20090048252-A1 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | PIK3CA, BTK, PI4KA | CYP11B2 1629/4885CYP11B1 1275/4885NAMPT 1598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.