SCHEMBL4244741

SCHEMBL4244741

CC(C)(C)c1ccc(CC2CCN(C(=O)NC(=O)c3ccc(OCc4ccccc4)cc3)CC2)cc1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC6A5 Q9Y345 5/20 0.53
NR4A2 P43354 1/20 0.52
RXRA P19793 1/20 0.52
RXRB P28702 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.51
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
CHRM4 P08173 2/20 0.50
POLB P06746 1/20 0.49
LTB4R Q15722 1/20 0.49
LTB4R2 Q9NPC1 1/20 0.49
GRIN2B Q13224 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4246343 0.92 MEN1 (0.55) SMN1; SMN2MEN1KMT2ACHRM4POLB
SCHEMBL4239342 0.90 SMN1; SMN2 (0.63) SMN1; SMN2MEN1KMT2APOLBLTB4R
SCHEMBL4245175 0.90 FAAH (0.58) SMN1; SMN2MEN1KMT2ACHRM4POLB
SCHEMBL5165692 0.89 ADAMTS5 (0.60) SMN1; SMN2MEN1KMT2ACHRM4POLB
SCHEMBL4244744 0.85 PARP10 (0.53) SLC6A5NR4A2RXRARXRBSMN1; SMN2
SCHEMBL4244566 0.85 ESRRG (0.49) MEN1KMT2APOLBGRIN2B
SCHEMBL4251982 0.83 DGAT1 (0.54) SLC6A5SMN1; SMN2MEN1KMT2ACHRM4
SCHEMBL5182248 0.82 SMN1; SMN2 (0.51) SLC6A5SMN1; SMN2MEN1KMT2ACHRM4
SCHEMBL4239616 0.80 FAAH (0.61) MEN1KMT2APOLBGRIN2B
SCHEMBL4242849 0.79 CHRM4 (0.52) SLC6A5SMN1; SMN2MEN1KMT2ACHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090170901-A1 Benzoyl Urea Derivatives RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2009-07-02 US disclosed
EP-1771429-A1 NEW BENZOYL UREA DERIVATIVES RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2007-04-11 EP disclosed
WO-2006010966-A1 NEW BENZOYL UREA DERIVATIVES Richter Gedeon Vegyészeti Gyár Rt. (HU) 2006-02-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090170901-A1 Benzoyl Urea Derivatives OPRM1, GRIN2C, GRIN3A SLC6A5 1995/4885NR4A2 286/4885RXRA 1862/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.