SCHEMBL4245201

SCHEMBL4245201

CN1CCCC[C@H]1[C@@H](NC(=O)c1cccc(C(F)(F)F)c1Cl)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 14/20 1.00
CTSS P25774 3/20 0.49
CTSK P43235 2/20 0.47
P2RX7 Q99572 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4589446 1.00 SLC6A9 (1.00) SLC6A9CTSSCTSKP2RX7
SCHEMBL4245203 1.00 SLC6A9 (1.00) SLC6A9CTSSCTSKP2RX7
Hydrochloric Acid SCHEMBL4588412 0.99 SLC6A9 (0.98) SLC6A9CTSSCTSKP2RX7
SCHEMBL1689574 0.99 SLC6A9 (0.98) SLC6A9CTSSCTSKP2RX7
SCHEMBL3533390 0.99 SLC6A9 (0.98) SLC6A9CTSSCTSKP2RX7
Hydrochloric Acid SCHEMBL4588406 0.99 SLC6A9 (0.98) SLC6A9CTSSCTSKP2RX7
Hydrochloric Acid SCHEMBL3533471 0.98 SLC6A9 (0.96) SLC6A9CTSSCTSKP2RX7
SCHEMBL1689575 0.97 SLC6A9 (0.94) SLC6A9CTSSCTSKP2RX7
SCHEMBL3535375 0.97 SLC6A9 (0.94) SLC6A9CTSSCTSKP2RX7
Hydrochloric Acid SCHEMBL3534258 0.96 SLC6A9 (0.93) SLC6A9CTSSCTSKP2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7326722-B2 N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives, their preparation and their application in therapy SANOFI-AVENTIS (FR) 2008-02-05 US claimed
US-20070197601-A1 Use of N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives in therapy SANOFI-AVENTIS (FR) 2007-08-23 US claimed
EP-1499589-B1 DERIVATIVES OF N-PHENYL(PIPERIDIN-2-YL)METHYL BENZAMIDE, THE PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS SANOFI AVENTIS (FR) 2007-05-02 EP claimed
US-20250262268-A1 Methods and Compositions for Inhibiting Viral Infection NEW YORK UNIVERSITY 2025-08-21 US disclosed
US-9096619-B2 Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy AbbVie Deutschland GmbH & Co. KG (DE) 2015-08-04 US disclosed
US-9096619-B2 Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy AbbVie Deutschland GmbH & Co. KG (DE) 2015-08-04 US disclosed
US-20130184238-A1 AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY AbbVie Deutschland GmbH & Co. KG (DE) 2013-07-18 US disclosed
US-20090175788-A1 RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER GLAXO GROUP LIMITED (GB) 2009-07-09 US disclosed
US-7326722-B2 N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives, their preparation and their application in therapy SANOFI-AVENTIS (FR) 2008-02-05 US disclosed
US-20070197601-A1 Use of N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives in therapy SANOFI-AVENTIS (FR) 2007-08-23 US disclosed
EP-1499589-B1 DERIVATIVES OF N-PHENYL(PIPERIDIN-2-YL)METHYL BENZAMIDE, THE PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS SANOFI AVENTIS (FR) 2007-05-02 EP disclosed
US-20050159450-A1 Derivative of n-[phenyl(piperidin-2-yl)methyl]benzamide, the preparation method thereof and application of same in therapeutics SANOFI-AVENTIS (FR) 2005-07-21 US disclosed
EP-1499589-A1 DERIVATIVES OF N-PHENYL(PIPERIDIN-2-YL)METHYL BENZAMIDE, THE PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS Sanofi-Aventis (FR) 2005-01-26 EP disclosed
WO-2003089411-A1 DERIVATIVES OF N-[PHENYL(PIPERIDIN-2-YL)METHYL]BENZAMIDE, THE PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS SANOFI-AVENTIS (FR) 2003-10-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070197601-A1 Use of N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives in therapy SLC1A2, SLC1A1, SLC1A5 SLC6A9 53/4885CTSS 3102/4885CTSK 3396/4885
US-20050159450-A1 Derivative of n-[phenyl(piperidin-2-yl)methyl]benzamide, the preparation method thereof and application of same in therapeutics NPR3, NR4A3, PRMT3 SLC6A9 4691/4885CTSS 3277/4885CTSK 3834/4885
US-20130184238-A1 AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY AADAT, GFPT1, BCAT1 SLC6A9 16/4885CTSS 3465/4885CTSK 4141/4885
US-20090175788-A1 RADIOLABELLED LIGAND FOR THE GLYCINE 1 TRANSPORTER SLC7A1, GLRA1, SLC6A5 SLC6A9 5/4885CTSS 2536/4885CTSK 1570/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.