Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.49 |
| ▸ | GOT1 | P17174 | 1/20 | 0.49 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.49 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075145 | 0.89 | CHRM2 (0.53) | MEN1KMT2AAADATGOT1KYAT1 | |
| SCHEMBL4075043 | 0.89 | CHRM2 (0.56) | MEN1KMT2AAADATGOT1KYAT1 | |
| SCHEMBL4250746 | 0.86 | MEN1 (0.53) | SMN1; SMN2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL4066762 | 0.86 | PYGL (0.54) | SMN1; SMN2MEN1KMT2AAADATGOT1 | |
| SCHEMBL4066626 | 0.86 | AADAT (0.49) | MEN1KMT2AAADATGOT1KYAT1 | |
| SCHEMBL4064775 | 0.83 | PYGL (0.52) | AADATGOT1KYAT1KYAT3ALDH1A1 | |
| SCHEMBL4069399 | 0.81 | CHRM2 (0.48) | MEN1KMT2AAADATGOT1KYAT1 | |
| SCHEMBL4073097 | 0.80 | CHRM2 (0.51) | MEN1KMT2AAADATGOT1KYAT1 | |
| SCHEMBL4072868 | 0.80 | L3MBTL1 (0.46) | SMN1; SMN2MEN1KMT2AAADATGOT1 | |
| SCHEMBL4891481 | 0.79 | AADAT (0.59) | AADATGOT1KYAT1KYAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099176-A1 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES | PROSIDION LIMITED (GB) | 2009-04-16 | — | — | US | disclosed |
| EP-1819332-B1 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES | PROSIDION LTD (GB) | 2009-03-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099176-A1 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES | PC, GOT2, PDK1 | SMN1; SMN2 3651/4885MEN1 4007/4885KMT2A 2295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.