Sugi Predict

Sugi Predict / Compounds / SCHEMBL4251848

SCHEMBL4251848

SCHEMBL4251848

CC(OC(=O)CCC(=O)O)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FFAR1 O14842 1/20 0.53
▸ HCAR2 Q8TDS4 1/20 0.51
▸ KDM4E B2RXH2 1/20 0.50
▸ MAPT P10636 1/20 0.50
▸ TSHR P16473 2/20 0.43
▸ LPAR1 Q92633 1/20 0.42
▸ USP5 P45974 1/20 0.42
▸ NR4A2 P43354 1/20 0.41
▸ ACE P12821 1/20 0.41
▸ ALDH1A1 P00352 3/20 0.40
▸ TP53 P04637 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ OPRM1 P35372 3/20 0.39
▸ CA12 O43570 1/20 0.39
▸ CA7 P43166 1/20 0.39
▸ CA9 Q16790 1/20 0.39
▸ CA14 Q9ULX7 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ CYP2D6 P10635 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21626578 1.00 FFAR1 (0.53) FFAR1HCAR2KDM4EMAPTTSHR
SCHEMBL11461421 0.94 HCAR2 (0.56) FFAR1HCAR2KDM4EMAPTTSHR
SCHEMBL19182 0.90 FFAR1 (0.50) FFAR1HCAR2KDM4EMAPTTSHR
SCHEMBL27884835 0.88 FFAR1 (0.49) FFAR1HCAR2KDM4EMAPTLPAR1
SCHEMBL1054349 0.87 HCAR2 (0.53) FFAR1HCAR2KDM4EMAPTTSHR
SCHEMBL8714551 0.86 HCAR2 (0.49) FFAR1HCAR2KDM4EMAPTTSHR
SCHEMBL6242067 0.86 HCAR2 (0.51) FFAR1HCAR2KDM4EMAPTTSHR
SCHEMBL28008075 0.86 HCAR2 (0.51) FFAR1HCAR2KDM4EMAPTTSHR
SCHEMBL5693685 0.86 HCAR2 (0.51) FFAR1HCAR2KDM4EMAPTTSHR
SCHEMBL585143 0.86 HCAR2 (0.51) FFAR1HCAR2KDM4EMAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118530412-A Binder for negative electrode, negative electrode slurry, negative electrode, and lithium battery 深圳好电科技有限公司 2024-08-23 — — CN claimed
US-20090123392-A1 FRAGRANCE ACCORDS TO COMBAT THE PERCEPTION OF BODY ODOR SYMRISE GMBH & CO. KG (DE) 2009-05-14 — — US claimed
CN-118530412-A Binder for negative electrode, negative electrode slurry, negative electrode, and lithium battery 深圳好电科技有限公司 2024-08-23 — — CN disclosed
CN-115197036-B Method for performing anti-mahalanobis hydrogen carboxylation reaction on photocatalytic olefin compound and carbon dioxide 中国科学院理化技术研究所 2024-01-23 — — CN disclosed
CN-115197036-A Method for carrying out anti-Ma hydrocarboxylation reaction on olefin compound and carbon dioxide by photocatalysis 中国科学院理化技术研究所 2022-10-18 — — CN disclosed
EP-3356356-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2021-05-26 — — EP disclosed
US-10894847-B2 Functionalized resin having a polar linker EASTMAN CHEMICAL COMPANY (US) 2021-01-19 — — US disclosed
US-10392371-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2019-08-27 — — US disclosed
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. 2019-06-13 — — US disclosed
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX INC (US) 2018-09-27 — — US disclosed
US-9732071-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2017-08-15 — — US disclosed
US-20170096418-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED 2017-04-06 — — US disclosed
US-20170087199-A1 COMPOSITIONS FOR DELIVERING A COOLING SENSATION SENOMYX INC (US) 2017-03-30 — — US disclosed
US-20160376263-A1 BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF SENOMYX INC (US) 2016-12-29 — — US disclosed
US-20160008297-A1 COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S) B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG (DE) 2016-01-14 — — US disclosed
US-20090123392-A1 FRAGRANCE ACCORDS TO COMBAT THE PERCEPTION OF BODY ODOR SYMRISE GMBH & CO. KG (DE) 2009-05-14 — — US disclosed
EP-1095022-A1 RETROVIRAL PROTEASE INHIBITORS G.D. SEARLE & CO. (US) 2001-05-02 — — EP disclosed
WO-2000002862-A1 RETROVIRAL PROTEASE INHIBITORS G.D. SEARLE & CO. (US) 2000-01-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160376263-A1 BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF TAS2R5, TAS1R1, TAS2R1 FFAR1 228/4885HCAR2 1934/4885KDM4E 1061/4885
US-10392371-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM4, TRPM6 FFAR1 1685/4885HCAR2 583/4885KDM4E 4171/4885
US-20160008297-A1 COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S) TRPV2, TRPV1, TRPM2 FFAR1 769/4885HCAR2 35/4885KDM4E 3182/4885
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 FFAR1 1242/4885HCAR2 542/4885KDM4E 4369/4885
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 FFAR1 1242/4885HCAR2 542/4885KDM4E 4369/4885
US-20170087199-A1 COMPOSITIONS FOR DELIVERING A COOLING SENSATION TRPA1, PDE6G, PDE6D FFAR1 282/4885HCAR2 522/4885KDM4E 3662/4885
US-20170096418-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 FFAR1 1242/4885HCAR2 542/4885KDM4E 4369/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.