Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.49 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL429914 | 0.95 | ALDH1A1 (0.48) | FFAR4FFAR1GPR84HSPD1BLM | |
| Citric Acid SCHEMBL28589360 | 0.92 | FFAR1 (0.61) | FFAR4FFAR1GPR84HSPD1BLM | |
| Citric Acid SCHEMBL27514700 | 0.92 | FFAR1 (0.61) | FFAR4FFAR1GPR84HSPD1BLM | |
| Citric Acid SCHEMBL427084 | 0.90 | GPR84 (0.51) | FFAR4FFAR1GPR84HSPD1BLM | |
| Citric Acid SCHEMBL429399 | 0.89 | GPR84 (0.54) | FFAR4FFAR1GPR84HSPD1BLM | |
| Citric Acid SCHEMBL426273 | 0.89 | ALDH1A1 (0.48) | FFAR4FFAR1GPR84HSPD1BLM | |
| Citric Acid SCHEMBL10006598 | 0.89 | ALDH1A1 (0.52) | FFAR4FFAR1GPR84HSPD1BLM | |
| Citric Acid SCHEMBL424025 | 0.88 | ALDH1A1 (0.47) | FFAR4FFAR1GPR84HSPD1BLM | |
| Citric Acid SCHEMBL30960325 | 0.87 | GPR84 (0.51) | FFAR4FFAR1GPR84HSPD1BLM | |
| Citric Acid SCHEMBL424009 | 0.86 | ALDH1A1 (0.48) | FFAR4FFAR1GPR84HSPD1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120020906-A1 | ANTIPERSPIRANT SPRAYS WITH ESTER OILS | HENKEL AG & CO. KGAA (DE) | 2012-01-26 | — | — | US | claimed |
| US-20170157025-A1 | TEXTILE FRIENDLY ANTIPERSPIRANT COMPOSITIONS | HENKEL AG & CO. KGAA (DE) | 2017-06-08 | — | — | US | disclosed |
| US-8828367-B2 | Water-free antiperspirant non-aerosols in which active substances are more readily released | HENKEL AG & CO. KGAA (DE) | 2014-09-09 | — | — | US | disclosed |
| US-8603445-B2 | Water-free antiperspirant sprays in which active substances are more readily released | HENKEL AG & CO. KGAA (DE) | 2013-12-10 | — | — | US | disclosed |
| US-20120177589-A1 | WATER-FREE ANTIPERSPIRANT NON-AEROSOLS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | HENKEL AG & CO. KGAA (DE) | 2012-07-12 | — | — | US | disclosed |
| US-20120171143-A1 | WATER-FREE ANTIPERSPIRANT SPRAYS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | HENKEL AG & CO. KGAA (DE) | 2012-07-05 | — | — | US | disclosed |
| US-20120020906-A1 | ANTIPERSPIRANT SPRAYS WITH ESTER OILS | HENKEL AG & CO. KGAA (DE) | 2012-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120020906-A1 | ANTIPERSPIRANT SPRAYS WITH ESTER OILS | CUTA, NAPEPLD, LIPE | FFAR4 47/4885FFAR1 8/4885GPR84 385/4885 |
| US-20120177589-A1 | WATER-FREE ANTIPERSPIRANT NON-AEROSOLS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | SIGMAR1, POLR1C, CUTA | FFAR4 163/4885FFAR1 34/4885GPR84 618/4885 |
| US-20120171143-A1 | WATER-FREE ANTIPERSPIRANT SPRAYS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | POLR1C, CUTA, PHOSPHO1 | FFAR4 225/4885FFAR1 45/4885GPR84 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.