Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | ACLY | P53396 | 6/20 | 0.45 |
| ▸ | CPT2 | P23786 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL424027 | 1.00 | ALDH1A1 (0.71) | ALDH1A1ACLYCPT2LMNAHMGCR | |
| Citric Acid SCHEMBL168115 | 1.00 | ALDH1A1 (0.71) | ALDH1A1ACLYCPT2LMNAHMGCR | |
| Citric Acid SCHEMBL27808233 | 1.00 | ALDH1A1 (0.71) | ALDH1A1ACLYCPT2LMNAHMGCR | |
| Citric Acid SCHEMBL426131 | 1.00 | ALDH1A1 (0.71) | ALDH1A1ACLYCPT2LMNAHMGCR | |
| Citric Acid SCHEMBL431228 | 1.00 | ALDH1A1 (0.71) | ALDH1A1ACLYCPT2LMNAHMGCR | |
| Citric Acid SCHEMBL30464701 | 1.00 | ALDH1A1 (0.71) | ALDH1A1ACLYCPT2LMNAHMGCR | |
| Citric Acid SCHEMBL8903778 | 0.98 | ALDH1A1 (0.68) | ALDH1A1ACLYCPT2LMNAHMGCR | |
| Citric Acid SCHEMBL2024217 | 0.98 | ALDH1A1 (0.68) | ALDH1A1ACLYCPT2LMNAHMGCR | |
| Citric Acid SCHEMBL10629086 | 0.98 | ALDH1A1 (0.68) | ALDH1A1ACLYCPT2LMNAHMGCR | |
| Citric Acid SCHEMBL27683192 | 0.96 | ALDH1A1 (0.65) | ALDH1A1ACLYCPT2LMNAHMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120020906-A1 | ANTIPERSPIRANT SPRAYS WITH ESTER OILS | HENKEL AG & CO. KGAA (DE) | 2012-01-26 | — | — | US | claimed |
| CN-118829433-A | Respiratory stimulant parenteral formulations | 依那拉治疗股份有限公司 | 2024-10-22 | — | — | CN | disclosed |
| CN-118488840-A | Methods of treating respiratory depression modulated by non-opioid agents | 依那拉治疗股份有限公司 | 2024-08-13 | — | — | CN | disclosed |
| CN-117529306-A | Nicotinamide Adenine Dinucleotide (NAD) compositions, methods of making and methods of using the same | 索维达解决方案有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-117479945-A | Large conductance potassium channel modulators, compositions thereof, methods of making and methods of using the same | 依那拉治疗股份有限公司 | 2024-01-30 | — | — | CN | disclosed |
| EP-3192499-B1 | CELLULOSE FIBRE BASED SUPPORT MATRICES FOR LAYERED PRODUCTS FOR ORAL AND PERORAL APPLICATION AND THEIR PREPARATION | GLATT GMBH (DE) | 2023-11-29 | — | — | EP | disclosed |
| CN-111511434-B | Oral delivery of active drug substances | 柏欧格瑞有限责任公司 | 2023-03-17 | — | — | CN | disclosed |
| CN-111491603-A | Composition for removing nail polish | 莱雅公司 | 2020-08-04 | — | — | CN | disclosed |
| US-20170157025-A1 | TEXTILE FRIENDLY ANTIPERSPIRANT COMPOSITIONS | HENKEL AG & CO. KGAA (DE) | 2017-06-08 | — | — | US | disclosed |
| US-9402762-B2 | Methods and devices for conduit occlusion | FEMASYS INC. | 2016-08-02 | — | — | US | disclosed |
| US-20150068531-A1 | METHODS AND DEVICES FOR CONDUIT OCCLUSION | FEMASYS INC. (US) | 2015-03-12 | — | — | US | disclosed |
| US-8828367-B2 | Water-free antiperspirant non-aerosols in which active substances are more readily released | HENKEL AG & CO. KGAA (DE) | 2014-09-09 | — | — | US | disclosed |
| US-8603445-B2 | Water-free antiperspirant sprays in which active substances are more readily released | HENKEL AG & CO. KGAA (DE) | 2013-12-10 | — | — | US | disclosed |
| US-20120177589-A1 | WATER-FREE ANTIPERSPIRANT NON-AEROSOLS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | HENKEL AG & CO. KGAA (DE) | 2012-07-12 | — | — | US | disclosed |
| US-20120171143-A1 | WATER-FREE ANTIPERSPIRANT SPRAYS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | HENKEL AG & CO. KGAA (DE) | 2012-07-05 | — | — | US | disclosed |
| US-20120020906-A1 | ANTIPERSPIRANT SPRAYS WITH ESTER OILS | HENKEL AG & CO. KGAA (DE) | 2012-01-26 | — | — | US | disclosed |
| US-5508394-A | BUILDERS IN LOW(OR NO)PHOSPHATE DETERGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1996-04-16 | — | — | US | disclosed |
| US-3859224-A | DETERGENT COMPOSITION CONTAINING, AS A BUILDER, THE SODIUM SALT OF GLYCEROL TRICITRATE | HOECHST AG | 1975-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120020906-A1 | ANTIPERSPIRANT SPRAYS WITH ESTER OILS | CUTA, NAPEPLD, LIPE | MEN1 2309/4885ALDH1A1 1032/4885ACLY 2333/4885 |
| US-20120177589-A1 | WATER-FREE ANTIPERSPIRANT NON-AEROSOLS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | SIGMAR1, POLR1C, CUTA | MEN1 4381/4885ALDH1A1 2601/4885ACLY 2961/4885 |
| US-20120171143-A1 | WATER-FREE ANTIPERSPIRANT SPRAYS IN WHICH ACTIVE SUBSTANCES ARE MORE READILY RELEASED | POLR1C, CUTA, PHOSPHO1 | MEN1 2543/4885ALDH1A1 1827/4885ACLY 2490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.