SCHEMBL4267262

SCHEMBL4267262

CCc1ccccc1[SiH](OC(C)(C)C)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 2/20 0.39
GABRB2 P47870 2/20 0.39
MAPT P10636 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
NPSR1 Q6W5P4 1/20 0.34
MGLL Q99685 1/20 0.32
CTSB P07858 1/20 0.32
RIPK1 Q13546 3/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
PKM P14618 1/20 0.31
TSHR P16473 1/20 0.31
KMT2A Q03164 1/20 0.31
HCAR1 Q9BXC0 1/20 0.30
HPGD P15428 1/20 0.30
ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4274033 0.78 GABRA1 (0.38) GABRA1GABRB2MAPTL3MBTL1NPSR1
SCHEMBL4267871 0.76 MAPT (0.40) GABRA1GABRB2MAPTL3MBTL1NPSR1
SCHEMBL4266365 0.74 ACHE (0.38) ALDH1A1TSHR
SCHEMBL4272041 0.73 GABRA1 (0.34) GABRA1GABRB2MAPTL3MBTL1NPSR1
SCHEMBL4281348 0.73 ALDH1A1 (0.40) GABRA1GABRB2MAPTL3MBTL1NPSR1
SCHEMBL27752414 0.72 L3MBTL1 (0.37) GABRA1GABRB2MAPTL3MBTL1NPSR1
SCHEMBL16011951 0.72 GABRA1 (0.38) GABRA1GABRB2MAPTL3MBTL1NPSR1
SCHEMBL3302642 0.71 GABRA1 (0.39) GABRA1GABRB2MAPTL3MBTL1NPSR1
SCHEMBL9745454 0.71 GABRA1 (0.45) GABRA1GABRB2MAPTMGLLCTSB
SCHEMBL4270396 0.70 MAPT (0.33) GABRA1GABRB2MAPTL3MBTL1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7604866-B2 Comprising silica particles and at least one binder compound; good mechanical strength and abrasion resistance ASAHI KASEI KABUSHIKI KAISHA (JP) 2009-10-20 US disclosed
US-20060269724-A1 Comprising silica particles and at least one binder compound; good mechanical strength and abrasion resistance ASAHI KASEI KABUSHIKI KAISHA (JP) 2006-11-30 US disclosed
US-20040077757-A1 Coating composition for use in producing an insulating thin film ASAHI KASEI KABUSHIKI KAISHA (JP) 2004-04-22 US disclosed