SCHEMBL4283882

SCHEMBL4283882

O=C(c1ccc(OC2CC2)cc1)c1c(O)cc(CO)cc1Cl

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 1/20 0.43
MAP4K4 O95819 1/20 0.41
EPHX2 P34913 10/20 0.39
FAAH O00519 3/20 0.39
RAF1 P04049 2/20 0.38
KCNH2 Q12809 2/20 0.38
HRH1 P35367 1/20 0.38
CCR3 P51677 1/20 0.38
OPRK1 P41145 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2J2 P51589 1/20 0.37
SENP8 Q96LD8 1/20 0.36
SENP6 Q9GZR1 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
TYK2 P29597 1/20 0.35
ADRB2 P07550 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4279745 0.85 PARP10 (0.39) PARP10MAP4K4EPHX2FAAHRAF1
SCHEMBL4279712 0.82 KDM4E (0.49) PARP10KMT2A
SCHEMBL4285539 0.82 MAP4K4 (0.45) PARP10MAP4K4EPHX2FAAHRAF1
SCHEMBL4288308 0.82 HPGD (0.50) PARP10RAF1MEN1KMT2A
SCHEMBL27767709 0.72 SLC5A1 (0.47) PARP10KMT2A
SCHEMBL1459360 0.70 SMN1; SMN2 (0.49) CYP2C9
SCHEMBL4279729 0.69 KDM4E (0.49) PARP10KMT2A
SCHEMBL16902893 0.69 ALDH1A1 (0.53) PARP10EPHX2FAAHHRH1
SCHEMBL12489770 0.69 ALDH1A1 (0.53) PARP10EPHX2FAAHHRH1
SCHEMBL4282822 0.69 RORC (0.41) PARP10MAP4K4EPHX2FAAHRAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 PARP10 2557/4885MAP4K4 1470/4885EPHX2 4388/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.