Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | SELL | P14151 | 1/20 | 0.38 |
| ▸ | SELP | P16109 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | HNF4A | P41235 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8976015 | 0.83 | MAPT (0.42) | KDM4EMAPTGAAPDE4BPDE4A | |
| SCHEMBL7026199 | 0.80 | SELL (0.57) | SELLSELPKDM4EHNF4AALDH1A1 | |
| SCHEMBL31509453 | 0.80 | SELL (0.57) | SELLSELPKDM4EHNF4AALDH1A1 | |
| SCHEMBL31275930 | 0.78 | ALOX5 (0.46) | ALOX5KDM4EMAPTRECQLGAA | |
| SCHEMBL9348187 | 0.78 | ALOX5 (0.46) | ALOX5KDM4EMAPTRECQLGAA | |
| SCHEMBL7426449 | 0.77 | BCAT2 (0.48) | SELLSELPKDM4EMAPTHNF4A | |
| SCHEMBL1286775 | 0.76 | MEN1 (0.51) | KDM4EMAPTGAAPDE4APDE4D | |
| SCHEMBL949284 | 0.72 | BACE1 (0.52) | ALOX5KDM4EMAPTRECQLGAA | |
| SCHEMBL27557303 | 0.71 | HSD17B10 (0.50) | ALOX5KDM4EMAPTRECQLGAA | |
| SCHEMBL27485021 | 0.71 | KDM4E (0.46) | ALOX5KDM4EMAPTRECQLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9061006-B2 | Compositions and methods for diagnosing and treating phenylketonuria (PKU) | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2015-06-23 | — | — | US | disclosed |
| US-20130344079-A1 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING PHENYLKETONURIA (PKU) | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2013-12-26 | — | — | US | disclosed |
| EP-1663199-B1 | COMPOSITIONS AND METHODS USING SAME FOR TREATING AMYLOID-ASSOCIATED DISEASES | UNIV TEL AVIV FUTURE TECH DEV (IL) | 2013-04-03 | — | — | EP | disclosed |
| US-20130078233-A1 | COMPOSITIONS AND METHODS USING SAME FOR TREATING AMYLOID-ASSOCIATED DISEASES | TEL AVIV UNIVERSITY FUTURE TECHNOLOGY DEVELOPMENT L.P. (IL) | 2013-03-28 | — | — | US | disclosed |
| US-8372880-B2 | Compositions and methods using same for treating amyloid-associated diseases | TEL AVIV UNIVERSITY FUTURE TECHNOLOGY DEVELOPMENT L.P. (IL) | 2013-02-12 | — | — | US | disclosed |
| WO-2012120518-A1 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING PHENYLKETONURIA (PKU) | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2012-09-13 | — | — | WO | disclosed |
| US-20090156471-A1 | Use of anti-amyloid agents for treating and typing pathogen infections | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2009-06-18 | — | — | US | disclosed |
| US-20060194777-A1 | Compositions and methods using same for treating amyloid-associated diseases | TEL AVIV UNIVERSITY FUTURE TECHNOLOGY DEVELOPMENT L.P. (IL) | 2006-08-31 | — | — | US | disclosed |
| EP-1663199-A1 | COMPOSITIONS AND METHODS USING SAME FOR TREATING AMYLOID-ASSOCIATED DISEASES | Tel Aviv University Future Technology Development L.P. (IL) | 2006-06-07 | — | — | EP | disclosed |
| WO-2006006172-A2 | USE OF ANTI-AMYLOID AGENTS FOR TREATING AND TYPING PATHOGEN INFECTIONS | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2006-01-19 | — | — | WO | disclosed |
| WO-2005027901-A1 | COMPOSITIONS AND METHODS USING SAME FOR TREATING AMYLOID-ASSOCIATED DISEASES | TEL AVIV UNIVERSITY FUTURE TECHNOLOGY DEVELOPMENT L.P. (IL) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194777-A1 | Compositions and methods using same for treating amyloid-associated diseases | APP, PSEN2, PSEN1 | ALOX5 468/4885SELL 4797/4885SELP 1381/4885 |
| US-20090156471-A1 | Use of anti-amyloid agents for treating and typing pathogen infections | TTR, HLA-DRB1, SERPINA3 | ALOX5 1001/4885SELL 1854/4885SELP 72/4885 |
| US-20130344079-A1 | COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING PHENYLKETONURIA (PKU) | PAH, PDXK, TTR | ALOX5 3622/4885SELL 4362/4885SELP 1590/4885 |
| US-20130078233-A1 | COMPOSITIONS AND METHODS USING SAME FOR TREATING AMYLOID-ASSOCIATED DISEASES | APP, PSEN2, PSEN1 | ALOX5 468/4885SELL 4797/4885SELP 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.