Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856269 | 0.79 | PKM (0.39) | KDM4EALDH1A1HPGDCYP19A1MAOB | |
| SCHEMBL7500811 | 0.78 | KDM4E (0.38) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL27660494 | 0.71 | KDM4E (0.40) | KDM4EALDH1A1HPGDHSD17B10SIRT1 | |
| SCHEMBL1922596 | 0.67 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10CA1 | |
| SCHEMBL31411168 | 0.65 | MAPT (0.51) | KDM4EALDH1A1HPGDHSD17B10CA1 | |
| SCHEMBL12316566 | 0.65 | MAPT (0.51) | KDM4EALDH1A1HPGDHSD17B10CA1 | |
| SCHEMBL9372790 | 0.65 | AR (0.47) | KDM4EALDH1A1HPGDHSD17B10CA1 | |
| SCHEMBL149892 | 0.64 | ALDH1A1 (0.37) | KDM4EALDH1A1HPGDHSD17B10L3MBTL1 | |
| SCHEMBL3679517 | 0.63 | CYP2C9 (0.35) | ALDH1A1SIRT1 | |
| SCHEMBL3273673 | 0.63 | KMT2A (0.50) | KDM4EALDH1A1HPGDHSD17B10CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143279-A1 | Methods and compositions for treating metabolic disorders | PC, PCK2, CS | KDM4E 3739/4885ALDH1A1 860/4885HPGD 503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.