SCHEMBL4289336

SCHEMBL4289336

COc1ccc(C(OC(C)=O)c2ccc(C)nc2OCc2ccccc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 2/20 0.42
PDE4A P27815 1/20 0.42
PDE4B Q07343 1/20 0.42
PDE4C Q08493 1/20 0.42
PDE4D Q08499 1/20 0.42
FFAR1 O14842 8/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
ACHE P22303 1/20 0.40
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
HTT P42858 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
GBA1 P04062 1/20 0.39
MAOB P27338 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4285312 0.88 CNR2 (0.37) CNR2FFAR1ALDH1A1LMNAHTT
SCHEMBL4285582 0.85 CNR2 (0.44) CNR2PDE4APDE4BPDE4CPDE4D
SCHEMBL4291107 0.82 CYP1A2 (0.46) CNR2PDE4APDE4BPDE4CPDE4D
SCHEMBL4289338 0.79 LRRK2 (0.43) PDE4APDE4BPDE4CPDE4DFFAR1
SCHEMBL4282622 0.73 L3MBTL1 (0.47) CNR2FFAR1ALDH1A1HTT
SCHEMBL5395059 0.73 ALDH1A1 (0.41) CNR2ALDH1A1LMNAHTTMAOB
SCHEMBL18877900 0.71 CNR2 (0.47) CNR2FFAR1ALDH1A1HTTMAOB
SCHEMBL4294561 0.70 LMNA (0.42) ALDH1A1LMNAHTTGBA1
SCHEMBL5381397 0.70 CYP1A2 (0.45) CNR2ALDH1A1LMNAHTTNPSR1
SCHEMBL4285318 0.69 RXRA (0.38) FFAR1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-05-28 US disclosed
EP-2048150-A1 BENZYL PHENYL GLUCOPYRANOSIDE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2009-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137499-A1 BENZYLPHENYL GLUCOPYRANOSIDE DERIVATIVE SLC5A1, SLC5A2, SLC2A1 CNR2 991/4885PDE4A 2266/4885PDE4B 2326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.