Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 19/20 | 0.74 |
| ▸ | MMP9 | P14780 | 19/20 | 0.74 |
| ▸ | MMP14 | P50281 | 15/20 | 0.74 |
| ▸ | MMP8 | P22894 | 10/20 | 0.74 |
| ▸ | MMP3 | P08254 | 8/20 | 0.74 |
| ▸ | MMP7 | P09237 | 4/20 | 0.74 |
| ▸ | MMP1 | P03956 | 2/20 | 0.74 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.74 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1529242 | 0.92 | MMP2 (0.70) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL2684163 | 0.85 | MMP2 (1.00) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL4294057 | 0.79 | MMP1 (0.56) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL10238440 | 0.75 | MMP2 (0.80) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL4290210 | 0.74 | MMP1 (0.61) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL10238448 | 0.74 | MMP2 (0.78) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL12020262 | 0.73 | MMP2 (0.69) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL2380308 | 0.72 | MMP2 (0.76) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL10238449 | 0.72 | MMP2 (0.74) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL7207010 | 0.72 | MMP1 (0.62) | MMP2MMP9MMP14MMP8MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090209615-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-08-20 | — | — | US | disclosed |
| US-7144917-B2 | Inhibitors of matrix metalloproteinases | WAYNE STATE UNIVERSITY (US) | 2006-12-05 | — | — | US | disclosed |
| WO-2006036928-A2 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | WAYNE STATE UNIVERSITY (US) | 2006-04-06 | — | — | WO | disclosed |
| EP-1309579-B1 | INHIBITORS OF MATRIX METALLOPROTEINASES | UNIV WAYNE STATE (US) | 2005-10-12 | — | — | EP | disclosed |
| US-20040127478-A1 | Inhibitors of matrix metalloproteinases | WAYNE STATE UNIVERSITY | 2004-07-01 | — | — | US | disclosed |
| US-6703415-B2 | EPOXIDES OR THIIRANE DERIVATIVES; TREATING OR PREVENTING CANCER, ANGIOGENESIS, ARTHRITIS, CONNECTIVE TISSUE DISEASE, CARDIOVASCULAR DISEASE, INFLAMMATION OR AUTOIMMUNE DISEASE; ANTIFERTILITY AGENTS | WAYNE STATE UNIVERSITY | 2004-03-09 | — | — | US | disclosed |
| EP-1309579-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) | 2003-05-14 | — | — | EP | disclosed |
| US-20020037916-A1 | Inhibitors of matrix metallaproteinases | UNITED STATES GOVERNMENT SECRETARY OF THE ARMY, THE | 2002-03-28 | — | — | US | disclosed |
| WO-2001092244-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES | WAYNE STATE UNIVERSITY (US) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037916-A1 | Inhibitors of matrix metallaproteinases | MMP12, MMP1, MMP3 | MMP2 20/4885MMP9 6/4885MMP14 9/4885 |
| US-20090209615-A1 | INHIBITORS OF MATRIX METALLOPROTEINASES TO TREAT NEUROLOGICAL DISORDERS | MMP9, MMP10, MMP17 | MMP2 13/4885MMP9 1/4885MMP14 8/4885 |
| US-20040127478-A1 | Inhibitors of matrix metalloproteinases | MMP1, MMP9, MMP3 | MMP2 21/4885MMP9 2/4885MMP14 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.