Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL37830 | 1.00 | MAPT (0.63) | MAPTKDM4EALDH1A1POLBKMT2A | |
| SCHEMBL29928397 | 1.00 | MAPT (0.63) | MAPTKDM4EALDH1A1POLBKMT2A | |
| SCHEMBL9755054 | 0.99 | MAPT (0.65) | MAPTKDM4EALDH1A1POLBKMT2A | |
| SCHEMBL4301793 | 0.95 | MAPT (0.70) | MAPTKDM4EALDH1A1POLBKMT2A | |
| SCHEMBL10932609 | 0.90 | MAPT (0.63) | MAPTKDM4EALDH1A1POLBKMT2A | |
| SCHEMBL7349997 | 0.89 | MAPT (0.62) | MAPTKDM4EALDH1A1POLBKMT2A | |
| SCHEMBL17875231 | 0.88 | MAPT (0.56) | MAPTKDM4EALDH1A1POLBKMT2A | |
| SCHEMBL27343040 | 0.86 | MAPT (0.73) | MAPTKDM4EALDH1A1POLBGAA | |
| SCHEMBL8536167 | 0.86 | PRSS1 (0.56) | MAPTKDM4EALDH1A1POLBKMT2A | |
| SCHEMBL14364287 | 0.85 | MAPT (0.60) | MAPTKDM4EALDH1A1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945798-B1 | METHOD FOR DETERMINING THE CLEAVABILITY OF SUBSTRATES | FORSCHUNGSZENTRUM BORSTEL (DE) | 2013-05-22 | — | — | EP | disclosed |
| US-20090258381-A1 | Methods for Determining the Cleavability of Substrates | FORSCHUNGSZENTRUM BORSTEL (DE) | 2009-10-15 | — | — | US | disclosed |
| EP-1945798-A2 | METHODS FOR DETERMINING THE CLEAVABILITY OF SUBSTRATES | Forschungszentrum Borstel (DE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007051605-A2 | METHODS FOR DETERMINING THE CLEAVABILITY OF SUBSTRATES | FORSCHUNGSZENTRUM BORSTEL (DE) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258381-A1 | Methods for Determining the Cleavability of Substrates | CTSF, ADAM17, ADAM10 | MAPT 4135/4885KDM4E 2739/4885ALDH1A1 2172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.