Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | TYR | P14679 | 2/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4303199 | 0.85 | XDH (0.37) | GABRA1GABRB2XDHKDM4ERNASEH1 | |
| SCHEMBL4314977 | 0.81 | TYR (0.46) | GABRA1GABRB2XDHKDM4ERNASEH1 | |
| SCHEMBL26521877 | 0.79 | GABRA1 (0.52) | GABRA1GABRB2XDHKDM4ECYP1A2 | |
| SCHEMBL9908791 | 0.79 | PTGS1 (0.45) | GABRA1GABRB2XDHKDM4EMEN1 | |
| SCHEMBL4235975 | 0.78 | KDM4E (0.39) | GABRA1GABRB2XDHKDM4EMEN1 | |
| SCHEMBL9816379 | 0.73 | GABRA1 (0.59) | GABRA1GABRB2XDHKDM4ERNASEH1 | |
| SCHEMBL9028982 | 0.73 | XDH (0.49) | GABRA1GABRB2XDHKDM4ERNASEH1 | |
| SCHEMBL9248515 | 0.73 | GABRA1 (0.40) | GABRA1GABRB2XDHKDM4EMEN1 | |
| SCHEMBL9202213 | 0.73 | AKR1B1 (0.60) | GABRA1GABRB2MEN1KMT2APOLB | |
| SCHEMBL7937251 | 0.71 | PTGS2 (0.49) | GABRA1GABRB2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090081134-A1 | Oral Care Compositions Comprising Tropolone Compounds and Essential Oils and Methods of Using The Same | PAN PAULINE | 2009-03-26 | — | — | US | disclosed |
| US-6924398-B2 | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same | WARNER-LAMBERT COMPANY LLC (US) | 2005-08-02 | — | — | US | disclosed |
| EP-1536759-A1 | ORAL CARE COMPOSITION COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS | Warner-Lambert Company LLC (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040204501-A1 | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same | CHENANGO ZERO LLC | 2004-10-14 | — | — | US | disclosed |
| US-20040185010-A1 | Oral care compositions comprising tropolone compounds and essential oils and methods of using the same | MCNEIL-PPC, INC | 2004-09-23 | — | — | US | disclosed |
| US-6787675-B2 | CHEMICAL STABILITY; SOLUBILITY; KILLING PATHOGENIC MICROORGANISMS RESPONSIBLE FOR ODOR, PLAQUE AND GINGIVITIS; MOUTHWASHES, RINSES | WARNER-LAMBERT COMPANY | 2004-09-07 | — | — | US | disclosed |
| WO-2004012692-A1 | ORAL CARE COMPOSITION COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-12 | — | — | WO | disclosed |
| US-6689342-B1 | DENTISTRY | WARNER-LAMBERT COMPANY | 2004-02-10 | — | — | US | disclosed |
| US-20040018216-A1 | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same | JOHNSON & JOHNSON CONSUMER INC. | 2004-01-29 | — | — | US | disclosed |
| US-20040018154-A1 | ORAL CARE COMPOSITIONS COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS AND METHODS OF USING THE SAME | MCNEIL-PPC, INC | 2004-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090081134-A1 | Oral Care Compositions Comprising Tropolone Compounds and Essential Oils and Methods of Using The Same | TMSB10, PIGS, TPM3 | GABRA1 2641/4885GABRB2 3843/4885XDH 1078/4885 |
| US-20040185010-A1 | Oral care compositions comprising tropolone compounds and essential oils and methods of using the same | TMSB10, PIGS, TPM3 | GABRA1 2641/4885GABRB2 3843/4885XDH 1078/4885 |
| US-20040018216-A1 | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same | TPM3, TPM4, TMSB10 | GABRA1 2326/4885GABRB2 3239/4885XDH 625/4885 |
| US-20040204501-A1 | Substituted tropolone compounds, oral care compositions containing the same and methods of using the same | TPM3, TPM4, TMSB10 | GABRA1 2326/4885GABRB2 3239/4885XDH 625/4885 |
| US-20040018154-A1 | ORAL CARE COMPOSITIONS COMPRISING TROPOLONE COMPOUNDS AND ESSENTIAL OILS AND METHODS OF USING THE SAME | TMSB10, PIGS, TPM3 | GABRA1 2641/4885GABRB2 3843/4885XDH 1078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.