Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4005701 | 0.81 | CXCR2 (0.36) | EPHX2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL4010564 | 0.80 | EPHX2 (0.35) | EPHX2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL4006918 | 0.78 | ALDH1A1 (0.45) | EPHX2HPGDALDH1A1KMT2ARECQL | |
| SCHEMBL4004804 | 0.78 | KMT2A (0.47) | EPHX2ALDH1A1RAB9ANPC1MEN1 | |
| SCHEMBL4004677 | 0.78 | KMT2A (0.47) | EPHX2ALDH1A1RAB9ANPC1MEN1 | |
| SCHEMBL4006598 | 0.78 | NPSR1 (0.41) | HPGDALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL4002524 | 0.77 | EPHX2 (0.48) | EPHX2ALDH1A1RAB9ANPC1MEN1 | |
| SCHEMBL4009267 | 0.77 | HSD11B1 (0.39) | EPHX2ALDH1A1RAB9ANPC1MEN1 | |
| SCHEMBL4010824 | 0.77 | EIF2AK3 (0.46) | RAB9ANPC1KDM4EPKM | |
| SCHEMBL4292846 | 0.77 | EPHX2 (0.45) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |