Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3120950 | 0.88 | ALDH1A1 (0.40) | ALDH1A1MAPK14ADRA1DRAB9ADRD2 | |
| SCHEMBL4304078 | 0.85 | MAPK14 (0.43) | ALDH1A1MAPK14HDAC1HDAC6DRD2 | |
| SCHEMBL7949180 | 0.85 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPK14MAPTL3MBTL1 | |
| SCHEMBL4308534 | 0.84 | ADRA1D (0.43) | ALDH1A1HPGDMAPK14ADRA1DDRD2 | |
| SCHEMBL4312756 | 0.83 | HDAC1 (0.47) | ALDH1A1RAB9AHDAC1HDAC6MAPT | |
| SCHEMBL4310271 | 0.83 | ALDH1A1 (0.41) | ALDH1A1MAPK14DRD2HTR2AHTR7 | |
| SCHEMBL3121013 | 0.82 | ALDH1A1 (0.40) | ALDH1A1MAPK14DRD2HTR2AHTR7 | |
| SCHEMBL4306692 | 0.80 | HDAC1 (0.42) | ALDH1A1RAB9AHDAC1HDAC6MAPT | |
| SCHEMBL7982425 | 0.80 | PKM (0.43) | ALDH1A1MAPK14HDAC1HDAC6MAPT | |
| SCHEMBL4312470 | 0.79 | ALDH1A1 (0.42) | ALDH1A1MAPK14POLBHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | claimed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |