Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4314936 | 1.00 | METAP2 (0.35) | METAP2ALDH1A1KMT2ARENCTSK | |
| SCHEMBL4314924 | 1.00 | METAP2 (0.35) | METAP2ALDH1A1KMT2ARENCTSK | |
| SCHEMBL4317290 | 0.83 | CACNA1B (0.38) | CTSK | |
| SCHEMBL5949181 | 0.80 | CTSK (0.50) | RENCTSK | |
| SCHEMBL4314512 | 0.78 | CTSK (0.38) | METAP2ALDH1A1KMT2ARENCTSK | |
| SCHEMBL6217307 | 0.72 | METAP2 (0.42) | METAP2ALDH1A1KMT2ARENCTSK | |
| SCHEMBL6740600 | 0.72 | CTSK (0.51) | CTSK | |
| SCHEMBL4312984 | 0.72 | CTSK (0.51) | CTSK | |
| SCHEMBL6740603 | 0.72 | CTSK (0.51) | CTSK | |
| Hydrochloric Acid SCHEMBL5983242 | 0.70 | CTSK (0.49) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7563784-B2 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-07-21 | — | — | US | disclosed |
| US-20060194787-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2006-08-31 | — | — | US | disclosed |
| US-7071184-B2 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2006-07-04 | — | — | US | disclosed |
| US-20040229863-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2004-11-18 | — | — | US | disclosed |
| US-20040044201-A1 | Protease inhibitors | GLAXOSMITHKLINE LLC | 2004-03-04 | — | — | US | disclosed |
| US-20030114437-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114437-A1 | Protease inhibitors | CTSS, CTSE, CTSF | METAP2 50/4885ALDH1A1 2215/4885KMT2A 2577/4885 |
| US-20060194787-A1 | Protease inhibitors | CTSK, CTSL, CTSZ | METAP2 577/4885ALDH1A1 2646/4885KMT2A 2453/4885 |
| US-20040044201-A1 | Protease inhibitors | CTSK, CTSE, CTSZ | METAP2 312/4885ALDH1A1 3139/4885KMT2A 2374/4885 |
| US-20040229863-A1 | Protease inhibitors | CTSS, CTSE, CTSF | METAP2 50/4885ALDH1A1 2215/4885KMT2A 2577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.