Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | GRK2 | P25098 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | GRK1 | Q15835 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4310162 | 0.91 | ALDH1A1 (0.47) | ALDH1A1MAPTL3MBTL1ROCK2ROCK1 | |
| SCHEMBL7946315 | 0.81 | MAPK14 (0.36) | MAPK14ALDH1A1MAPTL3MBTL1ROCK2 | |
| SCHEMBL7944882 | 0.80 | MAPT (0.49) | ALDH1A1MAPTL3MBTL1ROCK2ROCK1 | |
| SCHEMBL7982425 | 0.78 | PKM (0.43) | MAPK14ALDH1A1MAPTL3MBTL1ROCK2 | |
| SCHEMBL4306639 | 0.77 | MAPK14 (0.37) | MAPK14ALDH1A1MAPTL3MBTL1ROCK2 | |
| SCHEMBL7985830 | 0.77 | POLB (0.34) | POLBALDH1A1MAPTROCK2GRK2 | |
| SCHEMBL3120950 | 0.76 | ALDH1A1 (0.40) | MAPK14ALDH1A1MAPTL3MBTL1ROCK2 | |
| SCHEMBL4304078 | 0.76 | MAPK14 (0.43) | MAPK14ALDH1A1MAPTL3MBTL1ROCK2 | |
| SCHEMBL7938686 | 0.76 | ALDH1A1 (0.40) | MAPK14ALDH1A1ROCK2ROCK1PKM | |
| SCHEMBL4310271 | 0.75 | ALDH1A1 (0.41) | MAPK14ALDH1A1MAPTL3MBTL1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | claimed |