Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | HAT1 | O14929 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263677 | 0.89 | GABRA1 (0.45) | PKMMAPK14HAT1EP300ALDH1A1 | |
| SCHEMBL4566499 | 0.86 | MAPT (0.52) | ROCK2ROCK1ALDH1A1KMT2AMAPT | |
| SCHEMBL7938686 | 0.85 | ALDH1A1 (0.40) | PKMMAPK14HAT1EP300ROCK2 | |
| SCHEMBL3120950 | 0.84 | ALDH1A1 (0.40) | PKMMAPK14ROCK2ROCK1ALDH1A1 | |
| SCHEMBL4306639 | 0.83 | MAPK14 (0.37) | PKMMAPK14ROCK2ROCK1ALDH1A1 | |
| SCHEMBL7946315 | 0.82 | MAPK14 (0.36) | PKMMAPK14ROCK2ROCK1ALDH1A1 | |
| SCHEMBL4304078 | 0.81 | MAPK14 (0.43) | PKMMAPK14ROCK2ROCK1HDAC1 | |
| SCHEMBL4313368 | 0.80 | ALDH1A1 (0.43) | MAPK14HDAC1HDAC6ALDH1A1MAPT | |
| SCHEMBL4312756 | 0.80 | HDAC1 (0.47) | PKMROCK2ROCK1HDAC1HDAC6 | |
| SCHEMBL4310271 | 0.79 | ALDH1A1 (0.41) | MAPK14ROCK2ROCK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |