Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HAT1 | O14929 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3265771 | 0.87 | MAPT (0.50) | ALDH1A1TSHRKDRHPGDRECQL | |
| SCHEMBL7982425 | 0.85 | PKM (0.43) | ALDH1A1HAT1EP300PKMROCK2 | |
| SCHEMBL7946315 | 0.83 | MAPK14 (0.36) | ALDH1A1PKMROCK2ROCK1KMT2A | |
| SCHEMBL3263677 | 0.83 | GABRA1 (0.45) | ALDH1A1LMNAHAT1EP300HPGD | |
| SCHEMBL3120950 | 0.81 | ALDH1A1 (0.40) | ALDH1A1TSHRPKMNPC1RAB9A | |
| SCHEMBL4306639 | 0.81 | MAPK14 (0.37) | ALDH1A1PKMROCK2ROCK1KMT2A | |
| SCHEMBL4304078 | 0.79 | MAPK14 (0.43) | ALDH1A1PKMROCK2ROCK1KMT2A | |
| SCHEMBL4313368 | 0.78 | ALDH1A1 (0.43) | ALDH1A1HPGDRAB9AMAPK14 | |
| SCHEMBL4312756 | 0.78 | HDAC1 (0.47) | ALDH1A1LMNAPKMNPC1RAB9A | |
| SCHEMBL4310271 | 0.77 | ALDH1A1 (0.41) | ALDH1A1ROCK2ROCK1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |