Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.57 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4315470 | 1.00 | GPR119 (0.57) | GPR119USP30PIK3CDCHEK2ALDH1A1 | |
| SCHEMBL20168872 | 1.00 | GPR119 (0.57) | GPR119USP30PIK3CDCHEK2ALDH1A1 | |
| SCHEMBL2116540 | 0.92 | GPR119 (0.65) | GPR119USP30CHEK2ALDH1A1PDE4B | |
| SCHEMBL14862587 | 0.89 | USP30 (0.52) | GPR119USP30CHEK2ALDH1A1 | |
| SCHEMBL15376614 | 0.88 | GPR119 (0.58) | GPR119USP30PIK3CDCHEK2ALDH1A1 | |
| SCHEMBL20179924 | 0.88 | GPR119 (0.58) | GPR119USP30PIK3CDCHEK2ALDH1A1 | |
| SCHEMBL6189661 | 0.88 | GPR119 (0.58) | GPR119USP30PIK3CDCHEK2ALDH1A1 | |
| SCHEMBL699609 | 0.88 | GPR119 (0.58) | GPR119USP30PIK3CDCHEK2ALDH1A1 | |
| SCHEMBL31142651 | 0.88 | ALDH1A1 (0.60) | GPR119USP30PIK3CDALDH1A1PDE4B | |
| SCHEMBL699608 | 0.88 | GPR119 (0.58) | GPR119USP30PIK3CDCHEK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3891149-B1 | RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2026-01-28 | — | — | EP | disclosed |
| US-12312348-B2 | RET inhibitors, pharmaceutical compositions and uses thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2025-05-27 | — | — | US | disclosed |
| CN-111285873-B | RET inhibitor, pharmaceutical composition thereof and application thereof | 广东东阳光药业股份有限公司 | 2024-10-15 | — | — | CN | disclosed |
| CN-111285874-B | RET inhibitor, pharmaceutical composition thereof and application thereof | 广东东阳光药业股份有限公司 | 2024-08-09 | — | — | CN | disclosed |
| US-20220135557-A1 | RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-05-05 | — | — | US | disclosed |
| US-20220119382-A1 | RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-04-21 | — | — | US | disclosed |
| CN-111285873-A | RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2020-06-16 | — | — | CN | disclosed |
| CN-111285874-A | RET inhibitors, pharmaceutical compositions thereof and uses thereof | 广东东阳光药业有限公司 | 2020-06-16 | — | — | CN | disclosed |
| US-20090233969-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-09-17 | — | — | US | disclosed |
| US-7576102-B2 | Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF (IS) | 2009-08-18 | — | — | US | disclosed |
| EP-1963261-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007073407-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2007-06-28 | — | — | WO | disclosed |
| US-20070142432-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE CHEMISTRY, INC. (US) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119382-A1 | RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | RET, SLC10A2, REL | GPR119 170/4885USP30 2950/4885PIK3CD 2526/4885 |
| US-20220135557-A1 | RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | RET, REL, SLC10A2 | GPR119 246/4885USP30 2522/4885PIK3CD 2708/4885 |
| US-20090233969-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTC4S, LTB4R | GPR119 1988/4885USP30 2744/4885PIK3CD 4319/4885 |
| US-20070142432-A1 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTC4S, LTB4R | GPR119 1988/4885USP30 2744/4885PIK3CD 4319/4885 |
| US-12312348-B2 | RET inhibitors, pharmaceutical compositions and uses thereof | RET, SLC10A2, REL | GPR119 170/4885USP30 2950/4885PIK3CD 2526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.