Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18918257 | 0.82 | NQO1 (0.74) | NQO1PARP10PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL27895271 | 0.80 | NQO1 (0.70) | NQO1PARP10PRSS1PRSS2PRSS3 | |
| Tromethamine SCHEMBL3104874 | 0.75 | LMNA (0.43) | TDP1ALDH1A1KMT2A | |
| SCHEMBL3507784 | 0.71 | S1PR1 (0.55) | — | |
| 1,4-Diethoxybenzene SCHEMBL124015 | 0.71 | NQO1 (1.00) | NQO1PARP10PRSS1PRSS2PRSS3 | |
| 1,4-Diethoxybenzene SCHEMBL28186701 | 0.71 | NQO1 (1.00) | NQO1PARP10PRSS1PRSS2PRSS3 | |
| Tromethamine SCHEMBL7101299 | 0.70 | ALDH1A1 (0.42) | TSHRTDP1ADRA2ANPC1ALDH1A1 | |
| SCHEMBL12303396 | 0.69 | NQO1 (0.74) | NQO1PARP10PRSS1PRSS2PRSS3 | |
| 1,4-Diethoxybenzene SCHEMBL11794798 | 0.68 | NQO1 (0.93) | NQO1PARP10PRSS1PRSS2PRSS3 | |
| Tromethamine SCHEMBL1290395 | 0.68 | CES2 (0.42) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024024331-A1 | RESIN COMPOSITION | 味の素株式会社 | 2024-02-01 | — | — | WO | disclosed |
| US-20090062430-A1 | Epoxy Resin Composition for Sealing and Electronic Component Device | HITACHI CHEMICAL CO., LTD. (JP) | 2009-03-05 | — | — | US | disclosed |