Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL8936995 | 0.85 | ALDH1A1 (0.42) | ALDH1A1ALOX15TSHRHSD17B10HPGD | |
| SCHEMBL3951284 | 0.78 | ALDH1A1 (0.69) | ALDH1A1ALOX15TSHRHSD17B10HPGD | |
| Tromethamine SCHEMBL3104874 | 0.78 | LMNA (0.43) | ALDH1A1TDP1KMT2AMEN1LMNA | |
| SCHEMBL27616700 | 0.76 | ALDH1A1 (0.65) | ALDH1A1ALOX15TSHRHSD17B10HPGD | |
| SCHEMBL28247546 | 0.76 | ALDH1A1 (0.65) | ALDH1A1ALOX15TSHRHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL28948218 | 0.74 | ALDH1A1 (0.61) | ALDH1A1ALOX15TSHRHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL27995421 | 0.74 | ALDH1A1 (0.61) | ALDH1A1ALOX15TSHRHSD17B10HPGD | |
| Tromethamine SCHEMBL1290395 | 0.71 | CES2 (0.42) | KMT2AMEN1LMNA | |
| Tromethamine SCHEMBL4329786 | 0.70 | NQO1 (0.50) | ALDH1A1TSHRHPGDMAPTTDP1 | |
| SCHEMBL878369 | 0.70 | ALDH1A1 (0.55) | ALDH1A1ALOX15TSHRHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1323748-A1 | Curable resin compositions and process for preparing oligomers containing acrylate groups and substituted methacrylate groups | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2003-07-02 | — | — | EP | claimed |
| US-4013715-A | PROCESS FOR THE MANUFACTURE OF 2-HALO-ETHANE-PHOSPHONIC ACID DIHALIDES AND VINYL-PHOSPHONIC ACID DIHALIDES | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-22 | — | — | US | claimed |
| EP-0052419-B1 | PROCESS FOR THE SELECTIVE HYDROCARBOXYLATION OF PROPYLENE TO ISOBUTYRIC ACID | THE STANDARD OIL COMPANY (US) | 1985-01-09 | — | — | EP | disclosed |