Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4381548 | 1.00 | GPR119 (0.35) | GPR119NOX1ALDH1A1MT-CO2AKR1C3 | |
| SCHEMBL2791431 | 0.83 | SMN1; SMN2 (0.39) | ALDH1A1MT-CO2MAPTUSP30 | |
| SCHEMBL2791434 | 0.83 | SMN1; SMN2 (0.39) | ALDH1A1MT-CO2MAPTUSP30 | |
| SCHEMBL3989548 | 0.83 | KMT2A (0.40) | ALDH1A1MAPT | |
| SCHEMBL8539792 | 0.83 | SMN1; SMN2 (0.40) | ALDH1A1 | |
| SCHEMBL4324062 | 0.82 | TRPM8 (0.40) | NOX1ALDH1A1KDM4EMAPTTAS1R3 | |
| SCHEMBL4324066 | 0.82 | TRPM8 (0.40) | NOX1ALDH1A1KDM4EMAPTTAS1R3 | |
| SCHEMBL10521236 | 0.79 | ALDH1A1 (0.41) | ALDH1A1KDM4EMAPT | |
| SCHEMBL4330644 | 0.79 | PPARG (0.37) | KDM4EMAPTSLC6A4 | |
| SCHEMBL4330640 | 0.79 | PPARG (0.37) | KDM4EMAPTSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097384-A1 | INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS | AstraZeneca AB (SE) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008063116-A1 | INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS | ASTRAZENECA AB (SE) | 2008-05-29 | — | — | WO | disclosed |