Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.53 |
| ▸ | THRA | P10827 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 4/20 | 0.48 |
| ▸ | STS | P08842 | 6/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4330115 | 0.86 | SMPD1 (0.43) | ENPP1THRATHRBCA2SMN1; SMN2 | |
| SCHEMBL4326703 | 0.86 | MEN1 (0.59) | ENPP1THRATHRBSTSCA2 | |
| SCHEMBL3011724 | 0.82 | THRA (0.66) | THRATHRBGSK3BHAO1 | |
| SCHEMBL4342457 | 0.81 | GSK3B (0.62) | ENPP1GSK3BSMN1; SMN2EGFRMEN1 | |
| SCHEMBL17993333 | 0.80 | ENPP1 (0.60) | ENPP1CA2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4328040 | 0.79 | THRB (0.52) | THRATHRBGSK3BSMN1; SMN2HAO1 | |
| SCHEMBL11106388 | 0.79 | CA2 (0.55) | ENPP1STSCA2SMN1; SMN2 | |
| SCHEMBL3621448 | 0.78 | CA2 (0.54) | ENPP1CA2SMN1; SMN2 | |
| SCHEMBL4337232 | 0.78 | ALDH1A1 (0.59) | ENPP1GSK3BCA2SMN1; SMN2EGFR | |
| SCHEMBL8205823 | 0.78 | RARB (0.68) | THRATHRBGSK3BHAO1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146013-A1 | MYOSIN LIGHT CHAIN PHOSPHATASE INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2009-12-03 | — | — | WO | disclosed |