SCHEMBL434075

SCHEMBL434075

C=C(C)C(=O)OCCC[SiH2]O[Si](C)(C)C

nearest known ligand 0.50

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.50
THRB P10828 1/20 0.43
POLB P06746 1/20 0.39
APEX1 P27695 1/20 0.39
HTT P42858 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
ALDH1A1 P00352 2/20 0.38
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12959059 0.91 TSHR (0.43) TSHRTHRBPOLBAPEX1HTT
SCHEMBL13002352 0.91 TSHR (0.43) TSHRTHRBPOLBAPEX1HTT
SCHEMBL12958120 0.91 TSHR (0.43) TSHRTHRBPOLBAPEX1HTT
SCHEMBL12958128 0.91 TSHR (0.43) TSHRTHRBPOLBAPEX1HTT
SCHEMBL28830566 0.90 THRB (0.46) TSHRTHRBPOLBAPEX1HTT
SCHEMBL433972 0.89 TSHR (0.44) TSHRTHRBPOLBAPEX1HTT
SCHEMBL2142341 0.88 TSHR (0.45) TSHRTHRBPOLBAPEX1HTT
SCHEMBL17417867 0.88 TSHR (0.45) TSHRTHRBPOLBAPEX1HTT
SCHEMBL9744808 0.87 TSHR (0.47) TSHRTHRBPOLBAPEX1HTT
SCHEMBL8002867 0.87 TSHR (0.47) TSHRTHRBPOLBAPEX1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118240495-A Self-crosslinking packaging adhesive film, preparation method thereof and single glass assembly 江苏鹿山新材料有限公司 2024-06-25 CN claimed
CN-117229532-A Hydrogel cornea contact lens carrying hollow molecularly imprinted polymer microspheres and preparation method thereof 金陵科技学院 2023-12-15 CN claimed
CN-103959140-B There is the silicone hydrogels soft contact lens of wettable surface HOYA CORP. (JP) 2016-05-04 CN claimed
CN-105037629-A Silicone hydrogel with good resilience and preparation method and application method therefor UNIV SOUTHEAST 2015-11-11 CN claimed
CN-102675561-B silicone hydrogel with high water content FAR EASTERN NEW CENTURY CORPORATION (CN) 2014-10-22 CN claimed
CN-103959140-A Silicone hydrogel soft contact lens having wettable surface HOYA CORP 2014-07-30 CN claimed
CN-102115515-B Copolymer for improving wettability of silicone hydrogel, silicone hydrogel composition containing same and ophthalmic article prepared therefrom FAR EASTERN NEW CENTURY CORP 2014-06-18 CN claimed
CN-101687960-B Crosslink agents and dual radical cure polymer BAUSCH & LOMB 2013-10-30 CN claimed
US-8492513-B2 Method for enhancing water content of silicone hydrogel contact lens FAR EASTERN NEW CENTURY CORPORATION (TW) 2013-07-23 US claimed
CN-102675658-A Method for preparing polysiloxane hydrogel with high moisture content FAR EASTERN NEW CENTURY CORP 2012-09-19 CN claimed
CN-102675561-A Silicone hydrogel with high water content FAR EASTERN NEW CENTURY CORP 2012-09-19 CN claimed
US-20120214899-A1 METHOD FOR ENHANCING WATER CONTENT OF SILICONE HYDROGEL CONTACT LENS FAR EASTERN NEW CENTURY CORPORATION (TW) 2012-08-23 US claimed
US-20120214898-A1 SILICONE HYDROGEL WITH HIGH WATER CONTENT FAR EASTERN NEW CENTURY CORPORATION (TW) 2012-08-23 US claimed
CN-102464744-A Chlorinated polymers that enhance wettability of silicone hydrogels, silicone hydrogels comprising the same, and ophthalmic articles made therefrom FAR EASTERN NEW CENTURY CORP 2012-05-23 CN claimed
US-20120115979-A1 CHLORINATED POLYMER ENHANCING WETTABILITY OF SILICONE HYDROGEL, SILICONE HYDROGEL COMPRISING THE SAME AND OCULAR ARTICLE MADE THEREFROM FAR EASTERN NEW CENTURY CORPORATION (TW) 2012-05-10 US claimed
CN-102115515-A Copolymer for improving wettability of silicone hydrogel, silicone hydrogel composition containing same and ophthalmic article prepared therefrom FAR EASTERN NEW CENTURY CORP 2011-07-06 CN claimed
CN-101687960-A Linking agent and double-basis cure polymer BAUSCH & LOMB 2010-03-31 CN claimed
US-5258490-A Non-irritating soft gas permeable contact lens and process for producing same CHANG SING HSIUNG (US) 1993-11-02 US claimed
EP-0539099-A2 Repositionable optical cover for monitors OPTICAL COATING LABORATORY, INC. (US) 1993-04-28 EP claimed
US-20260022252-A1 ULTRAVIOLET-CURABLE COMPOSITION AND USE THEREOF DOW TORAY CO LTD (JP) 2026-01-22 US disclosed
CN-119882270-A Soft contact lens and application thereof in infrared visual imaging detection 中国科学技术大学 2025-04-25 CN disclosed
US-20240409750-A1 HIGH ENERGY RAY-CURABLE COMPOSITION AND USE OF SAME DOW TORAY CO LTD (JP) 2024-12-12 US disclosed
CN-118271354-A Q-type end-capping agent, Q-type branched polysiloxane and preparation method and application thereof 万华化学集团股份有限公司 2024-07-02 CN disclosed
CN-118240495-A Self-crosslinking packaging adhesive film, preparation method thereof and single glass assembly 江苏鹿山新材料有限公司 2024-06-25 CN disclosed
CN-117801422-A Polypropylene composite material capable of preventing rats from biting and preparation method thereof 广东圆融新材料有限公司 2024-04-02 CN disclosed
CN-117229532-A Hydrogel cornea contact lens carrying hollow molecularly imprinted polymer microspheres and preparation method thereof 金陵科技学院 2023-12-15 CN disclosed
CN-117025095-A Primer for condensed type organic silicon pressure-sensitive adhesive and preparation method thereof 深圳市康利邦科技有限公司 2023-11-10 CN disclosed
CN-116655989-A Preparation method of silane-functionalized polyolefin material 浙江祥邦科技股份有限公司 2023-08-29 CN disclosed
CN-111234136-B Photo-curing organic silicon resin system and preparation method of photo-curing film 佛山市天宝利硅工程科技有限公司 2023-04-21 CN disclosed
CN-114173748-A Polymer coating agent having both excellent water-and oil-repellent characteristics and cosmetic composition containing the same having excellent makeup durability 株式会社LG生活健康 2022-03-11 CN disclosed
CN-113166340-A Hydrogel composition 眼科公司 2021-07-23 CN disclosed
CN-111234136-A Preparation method of photocuring organic silicon resin system and photocuring film 佛山市天宝利硅工程科技有限公司 2020-06-05 CN disclosed
CN-110964353-A Solution composition for repairing damaged stage, method for repairing damaged stage, and method for antistatic coating of damaged stage 拓普纳诺斯株式会社 2020-04-07 CN disclosed
CN-106163647-B Membrane manufacturing method 应用仿生学有限公司 2020-03-03 CN disclosed
CN-104898187-B Ophthalmic devices comprising photochromic materials having reactive substituents INNOTECH, INC., JOHNSON AND JOHNSON VISION CARE (US) 2019-12-10 CN disclosed
US-9968542-B2 Makeup base for skin removable with warm water SHISEIDO COMPANY, LTD. (JP) 2018-05-15 US disclosed
US-9482950-B2 Curable composition for imprints, pattern-forming method and pattern FUJIFILM CORPORATION (JP) 2016-11-01 US disclosed
CN-103959140-B There is the silicone hydrogels soft contact lens of wettable surface HOYA CORP. (JP) 2016-05-04 CN disclosed
CN-105037629-A Silicone hydrogel with good resilience and preparation method and application method therefor UNIV SOUTHEAST 2015-11-11 CN disclosed
US-9150706-B2 Photo curable resin composition, imaging display device and production method thereof HITACHI CHEMICAL COMPANY, LTD. (JP) 2015-10-06 US disclosed
US-20150272853-A1 MAKEUP BASE FOR SKIN REMOVABLE WITH WARM WATER SHISEIDO COMPANY, LTD. (JP) 2015-10-01 US disclosed
US-20150225601-A1 COMPOSITION FOR PATTERN FORMATION, AND PATTERN-FORMING METHOD JSR CORPORATION (JP) 2015-08-13 US disclosed
CN-102675561-B silicone hydrogel with high water content FAR EASTERN NEW CENTURY CORPORATION (CN) 2014-10-22 CN disclosed
CN-101915946-B Ophthalmic devices comprising photochromic materials with reactive substituents JOHNSON & JOHNSON VISION CARE 2014-08-20 CN disclosed
CN-103959140-A Silicone hydrogel soft contact lens having wettable surface HOYA CORP 2014-07-30 CN disclosed
CN-102115515-B Copolymer for improving wettability of silicone hydrogel, silicone hydrogel composition containing same and ophthalmic article prepared therefrom FAR EASTERN NEW CENTURY CORP 2014-06-18 CN disclosed
US-20140050900-A1 CURABLE COMPOSITION FOR IMPRINTS, PATTERN-FORMING METHOD AND PATTERN FUJIFILM CORPORATION (JP) 2014-02-20 US disclosed
US-20130286604-A1 PHOTO CURABLE RESIN COMPOSITION, IMAGING DISPLAY DEVICE AND PRODUCTION METHOD THEREOF HITACHI CHEMICAL COMPANY, LTD. (JP) 2013-10-31 US disclosed
CN-101624502-B Antifouling coating composition and underwater structure using the same SHINETSU CHEMICAL CO 2013-09-04 CN disclosed
US-8492513-B2 Method for enhancing water content of silicone hydrogel contact lens FAR EASTERN NEW CENTURY CORPORATION (TW) 2013-07-23 US disclosed
CN-102675658-A Method for preparing polysiloxane hydrogel with high moisture content FAR EASTERN NEW CENTURY CORP 2012-09-19 CN disclosed
CN-102675561-A Silicone hydrogel with high water content FAR EASTERN NEW CENTURY CORP 2012-09-19 CN disclosed
US-20120214898-A1 SILICONE HYDROGEL WITH HIGH WATER CONTENT FAR EASTERN NEW CENTURY CORPORATION (TW) 2012-08-23 US disclosed
US-20120214899-A1 METHOD FOR ENHANCING WATER CONTENT OF SILICONE HYDROGEL CONTACT LENS FAR EASTERN NEW CENTURY CORPORATION (TW) 2012-08-23 US disclosed
CN-101137691-B Hydrogel copolymers for biomedical devices BAUSCH & LOMB INCORPROATED 2012-06-20 CN disclosed
CN-102464744-A Chlorinated polymers that enhance wettability of silicone hydrogels, silicone hydrogels comprising the same, and ophthalmic articles made therefrom FAR EASTERN NEW CENTURY CORP 2012-05-23 CN disclosed
US-20120115979-A1 CHLORINATED POLYMER ENHANCING WETTABILITY OF SILICONE HYDROGEL, SILICONE HYDROGEL COMPRISING THE SAME AND OCULAR ARTICLE MADE THEREFROM FAR EASTERN NEW CENTURY CORPORATION (TW) 2012-05-10 US disclosed
US-20120064019-A1 COSMETIC COMPOSITION FOR MAKING-UP AND/OR CARING FOR KERATIN MATERIALS AND MAKE-UP METHOD L'OREAL (FR) 2012-03-15 US disclosed
CN-1950460-B Wettable hydrogels comprising acyclic polyamides JOHNSON & JOHNSON VISION CARE 2012-03-14 CN disclosed
CN-101094879-B Polysiloxane prepolymers for biomedical devices BAUSCH & LOMB 2011-08-10 CN disclosed
CN-102115515-A Copolymer for improving wettability of silicone hydrogel, silicone hydrogel composition containing same and ophthalmic article prepared therefrom FAR EASTERN NEW CENTURY CORP 2011-07-06 CN disclosed
CN-101094878-B Polysiloxane prepolymers for biomedical devices BAUSCH & LOMB 2011-04-13 CN disclosed
CN-101915946-A The Ophthalmoligic instrument that comprises photochromic material with reactive substituents JOHNSON & JOHNSON VISION CARE 2010-12-15 CN disclosed
US-7776982-B2 Interpolymer of an alpha-substituted acrylate having a fluoroalkyl group and optionally perfluoroalkoxy units and an unsaturated terminated siloxane; imparts excellent water repellency, oil repellency, soil resistance and feeling to textiles, particularly carpets DAIKIN INDUSTRIES, LTD. (JP) 2010-08-17 US disclosed
CN-101624502-A Antifouling coating composition and underwater structure using the same SHINETSU CHEMICAL CO 2010-01-13 CN disclosed
CN-100522255-C Antimicrobial lenses and methods of their use JOHNSON & JOHNSON VISION CARE (US) 2009-08-05 CN disclosed
EP-1507811-A4 POLYMER HAVING CHARGED UNITS COMMW SCIENT IND RES ORG (AU) 2008-09-24 EP disclosed
CN-101208621-A Ophthalmic devices comprising photochromic materials having reactive substituents JOHNSON & JOHNSON VISION CARE (US) 2008-06-25 CN disclosed
CN-101137691-A Hydrogel copolymers for biomedical devices BAUSCH & LOMB (US) 2008-03-05 CN disclosed
US-20080047469-A1 Highly Scratch-Resistant and Highly Elastic Coating Agents Based on Alkoxysilane Functional Components BASF COATINGS AG (DE) 2008-02-28 US disclosed
CN-101094878-A Polysiloxane prepolymers for biomedical devices BAUSCH & LOMB (US) 2007-12-26 CN disclosed
CN-101094879-A Polysiloxane prepolymers for biomedical devices BAUSCH & LOMB (US) 2007-12-26 CN disclosed
US-20070282204-A1 Array-type ultrasonic probe and ultrasonic diagnostic apparatus KABUSHIKI KAISHA TOSHIBA 2007-12-06 US disclosed
EP-1802719-A1 HIGHLY SCRATCH-RESISTANT AND HIGHLY ELASTIC COATING AGENTS BASED ON ALKOXYSILANE-FUNCTIONAL COMPONENTS BASF Coatings AG (DE) 2007-07-04 EP disclosed
CN-1976964-A Novel prepolymers for improved surface modification of contact lenses BAUSCH & LOMB (US) 2007-06-06 CN disclosed
CN-1956741-A Process for extracting biomedical devices BAUSCH & LOMB INC BAUSCH & LOM (US) 2007-05-02 CN disclosed
CN-1950460-A Wettable hydrogels comprising acyclic polyamides JOHNSON & JOHNSON VISION CARE (US) 2007-04-18 CN disclosed
CN-1906222-A Novel prepolymers for improved surface modification of contact lenses BAUSCH & LOMB (US) 2007-01-31 CN disclosed
CN-1864752-A Antimicrobial lenses and methods of their use JOHNSON & JOHNSON VISION CARE (US) 2006-11-22 CN disclosed
CN-1285386-C Antimicrobial lenses and methods of use thereof JOHNSON & JOHNSON VISION CARE (US) 2006-11-22 CN disclosed
CN-1260255-C Method for polymerizing lenses BAUSCH & LOMB (US) 2006-06-21 CN disclosed
WO-2006042584-A1 HIGHLY SCRATCH-RESISTANT AND HIGHLY ELASTIC COATING AGENTS BASED ON ALKOXYSILANE-FUNCTIONAL COMPONENTS BASF COATINGS AG (DE) 2006-04-27 WO disclosed
CN-1735502-A Methods for the extraction of contact lenses JOHNSON & JOHNSON VISION CARE (US) 2006-02-15 CN disclosed
EP-1507811-A1 POLYMER HAVING CHARGED UNITS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2005-02-23 EP disclosed
CN-1582303-A Method of polymerizing lenses BAUSCH & LOMB (US) 2005-02-16 CN disclosed
CN-1558779-A Antimicrobial lenses and methods of use thereof 庄臣及庄臣视力保护公司 2004-12-29 CN disclosed
WO-2003097711-A1 POLYMER HAVING CHARGED UNITS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2003-11-27 WO disclosed
EP-1192194-A1 PROCESS FOR THE MANUFACTURE OF MOLDINGS Novartis AG (CH) 2002-04-03 EP disclosed
EP-1159317-A1 NEW BIOMATERIALS Novartis AG (CH) 2001-12-05 EP disclosed
US-6326011-B1 COATING CAN MODIFY NATURE OF HAIR, IMPROVE MAKE-UP RETENTION, AND PROVIDE SKIN-PROTECTING, CAN IMPART WATER-REPELLENCY, RESISTANCE TO FOULING, SUITABILITY AS SIZING AND CREASE RESISTANCE TO FIBERS CAN IMPROVE SKIN-CLEANING SHISEIDO CO., LTD. (JP) 2001-12-04 US disclosed
CN-1301353-A Method of polymerizing contact lenses BAUSCH & LOMB INCORP (US) 2001-06-27 CN disclosed
WO-2000078830-A1 PROCESS FOR THE MANUFACTURE OF MOLDINGS NOVARTIS AG (CH) 2000-12-28 WO disclosed
WO-2000049058-A1 NEW BIOMATERIALS NOVARTIS AG (CH) 2000-08-24 WO disclosed
EP-0684033-B1 Adhesive composition for dental treatment SUN MEDICAL CO LTD (JP) 2000-07-19 EP disclosed
CN-1047850-C Improved itaconate copolymeric compositions for contact lenses POLYMER TECHNOLOGY CORP (US) 1999-12-29 CN disclosed
EP-0918069-A1 COPOLYMER CONTAINING REACTIVE SILYL GROUPS, COMPOSITION CONTAINING THE SAME, AND METHOD OF TREATMENT WITH THE SAME SHISEIDO COMPANY LIMITED (JP) 1999-05-26 EP disclosed
US-5753763-A Process for preparing liquid toners with hydrocarbon solvents MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-05-19 US disclosed
EP-0819258-A1 EXTENDED WEAR OPHTHALMIC LENS Novartis AG (CH) 1998-01-21 EP disclosed
EP-0819141-A1 CELL GROWTH SUBSTRATE POLYMER Novartis AG (CH) 1998-01-21 EP disclosed
US-5700875-A POLYMERIZABLE MONOMER MIXTURE HAVING ACIDIC GROUPS, A POLYMER OF UNSATURATED MONOMERS AND A POLYMERIZATION INITIATOR SUN MEDICAL CO., LTD. (JP) 1997-12-23 US disclosed
WO-1996031548-A1 CELL GROWTH SUBSTRATE POLYMER NOVARTIS AG (CH) 1996-10-10 WO disclosed
WO-1996031792-A1 EXTENDED WEAR OPHTHALMIC LENS NOVARTIS AG (CH) 1996-10-10 WO disclosed
CN-1123056-A Itaconate copolymer compositions for contact lenses POLYMER TECHNOLOGY CORP (US) 1996-05-22 CN disclosed
EP-0684033-A1 Adhesive composition for dental treatment SUN MEDICAL CO., LTD. (JP) 1995-11-29 EP disclosed
EP-0438496-B1 CONFORMABLE BANDAGE AND COATING MATERIAL ROCHAL IND INC A FLORIDA CORP (US) 1995-07-12 EP disclosed
US-4987893-A Conformable bandage and coating material ROCHAL INDUSTRIES, INC. (US) 1991-01-29 US disclosed
WO-1990003809-A1 CONFORMABLE BANDAGE AND COATING MATERIAL ROCHAL INDUSTRIES, INC. (US) 1990-04-19 WO disclosed
EP-0294515-A2 Contact lens material Menicon Co., Ltd. (JP) 1988-12-14 EP disclosed
EP-0294515-A2 Contact lens material Menicon Co., Ltd. (JP) 1988-12-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120064019-A1 COSMETIC COMPOSITION FOR MAKING-UP AND/OR CARING FOR KERATIN MATERIALS AND MAKE-UP METHOD PLOD3, ALOX15, ELOVL1 TSHR 2894/4885THRB 747/4885POLB 563/4885
US-20260022252-A1 ULTRAVIOLET-CURABLE COMPOSITION AND USE THEREOF SEM1, COL1A1, XRCC6 TSHR 1999/4885THRB 543/4885POLB 161/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.