Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Methane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL472806 | 0.97 | ALDH1A1 (0.30) | ALDH1A1HSD17B10PTGS2HPGD | |
| Water SCHEMBL9852692 | 0.93 | ALDH1A1 (0.32) | ALDH1A1HSD17B10PTGS2HPGDTSHR | |
| Water SCHEMBL7513746 | 0.93 | ALDH1A1 (0.32) | ALDH1A1HSD17B10PTGS2HPGDTSHR | |
| SCHEMBL21485 | 0.93 | — | — | |
| SCHEMBL11483005 | 0.90 | ALDH1A1 (0.33) | ALDH1A1HSD17B10PTGS2HPGDTSHR | |
| Methyl Alcohol SCHEMBL2102608 | 0.90 | ALDH1A1 (0.33) | ALDH1A1HSD17B10PTGS2HPGDTSHR | |
| Ammonia Solution, Strong SCHEMBL1086703 | 0.90 | ALDH1A1 (0.33) | ALDH1A1HSD17B10PTGS2HPGDTSHR | |
| Methylamine SCHEMBL6742860 | 0.90 | ALDH1A1 (0.33) | ALDH1A1HSD17B10PTGS2HPGDTSHR | |
| SCHEMBL930240 | 0.90 | ALDH1A1 (0.33) | ALDH1A1HSD17B10PTGS2HPGDTSHR | |
| Selenium SCHEMBL11494964 | 0.90 | ALDH1A1 (0.33) | ALDH1A1HSD17B10PTGS2HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2596039-A1 | SEALANT&ADHESIVE USING GREEN PREPOLYMER | Construction Research & Technology GmbH (DE) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012010559-A1 | SEALANT&ADHESIVE USING GREEN PREPOLYMER | CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) | 2012-01-26 | — | — | WO | disclosed |
| EP-1668147-A2 | DETECTION OF LIVING CELLS IN POLYMERS OR PIGMENTS | EASTMAN CHEMICAL COMPANY (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005033329-A2 | DETECTION OF LIVING CELLS IN POLYMERS OR PIGMENTS | EASTMAN CHEMICAL COMPANY (US) | 2005-04-14 | — | — | WO | disclosed |
| WO-2002040560-A1 | WATERBORNE ACRYLIC MODIFIED ALKYD RESINS | EASTMAN CHEMICAL COMPANY (US) | 2002-05-23 | — | — | WO | disclosed |
| EP-0958306-A1 | CARBOXYALKYL CELLULOSE ESTERS | EASTMAN CHEMICAL COMPANY (US) | 1999-11-24 | — | — | EP | disclosed |
| EP-0877764-A1 | SMALL PARTICLE SIZE POLYESTER/ACRYLIC HYBRID LATEXES | EASTMAN CHEMICAL COMPANY (US) | 1998-11-18 | — | — | EP | disclosed |
| WO-1998033821-A1 | CARBOXYALKYL CELLULOSE ESTERS | EASTMAN CHEMICAL COMPANY (US) | 1998-08-06 | — | — | WO | disclosed |
| EP-0820478-A1 | WATERBORNE POLYMERS HAVING PENDANT ALLYL GROUPS | EASTMAN CHEMICAL COMPANY (US) | 1998-01-28 | — | — | EP | disclosed |
| EP-0820477-A2 | WATERBORNE POLYMERS WITH PENDANT CROSSLINKABLE GROUPS | EASTMAN CHEMICAL COMPANY (US) | 1998-01-28 | — | — | EP | disclosed |
| WO-1995012640-A1 | THERMOSETTING COATING COMPOSITIONS | EASTMAN CHEMICAL COMPANY (US) | 1995-05-11 | — | — | WO | disclosed |
| WO-1995011220-A1 | THERMOSETTING COATING COMPOSITIONS | EASTMAN CHEMICAL COMPANY (US) | 1995-04-27 | — | — | WO | disclosed |
| EP-0641305-A1 | THERMOSETTING COATING COMPOSITIONS. | EASTMAN CHEM CO (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1994025535-A1 | THERMOSETTING COATING COMPOSITIONS | EASTMAN CHEMICAL COMPANY (US) | 1994-11-10 | — | — | WO | disclosed |
| WO-1994016026-A1 | WATER-BORNE COATING COMPOSITIONS | EASTMAN CHEMICAL COMPANY (US) | 1994-07-21 | — | — | WO | disclosed |
| WO-1994014871-A1 | POLYESTER COATINGS CONTAINING COVALENTLY-BOUND MESOGENIC MONOMERS | EASTMAN KODAK COMPANY (US) | 1994-07-07 | — | — | WO | disclosed |
| WO-1994012557-A1 | THERMOSETTING COATING COMPOSITIONS | EASTMAN CHEMICAL COMPANY (US) | 1994-06-09 | — | — | WO | disclosed |
| US-5306567-A | Polyesters containing hydroxy functionalized isophthalate ester moieties; acid resistance, impact strength | EASTMAN KODAK COMPANY (US) | 1994-04-26 | — | — | US | disclosed |
| WO-1992022617-A1 | THERMOSETTING COATING COMPOSITIONS | EASTMAN CHEMICAL COMPANY (US) | 1992-12-23 | — | — | WO | disclosed |
| WO-1992021646-A1 | THERMOSETTING COATING COMPOSITIONS | EASTMAN KODAK COMPANY (US) | 1992-12-10 | — | — | WO | disclosed |