Methane

Methane

SCHEMBL472806

C.CNC(O)=S.NC(O)=S.O.[KH]

nearest known ligand 0.31

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Methane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PTGS2 known ✓ P35354 1/20 0.30
ALDH1A1 P00352 2/20 0.30
HSD17B10 Q99714 2/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methane SCHEMBL434751 0.97 ALDH1A1 (0.32) ALDH1A1HSD17B10PTGS2HPGD
Water SCHEMBL7513746 0.97 ALDH1A1 (0.32) ALDH1A1HSD17B10PTGS2HPGD
SCHEMBL930240 0.94 ALDH1A1 (0.33) ALDH1A1HSD17B10PTGS2HPGD
Methyl Alcohol SCHEMBL988004 0.90 ALDH1A1 (0.32) ALDH1A1HSD17B10PTGS2HPGD
Water SCHEMBL9852692 0.90 ALDH1A1 (0.32) ALDH1A1HSD17B10PTGS2HPGD
SCHEMBL21485 0.90
Methyl Alcohol SCHEMBL2102608 0.87 ALDH1A1 (0.33) ALDH1A1HSD17B10PTGS2HPGD
SCHEMBL11483005 0.87 ALDH1A1 (0.33) ALDH1A1HSD17B10PTGS2HPGD
Ammonia Solution, Strong SCHEMBL1086703 0.87 ALDH1A1 (0.33) ALDH1A1HSD17B10PTGS2HPGD
Methylamine SCHEMBL6742860 0.87 ALDH1A1 (0.33) ALDH1A1HSD17B10PTGS2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 239 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090227710-A1 SILANE-TERMINATED POLYURETHANES WITH HIGH STRENGTH AND HIGH ELONGATION CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) 2009-09-10 US claimed
EP-1582541-A2 Silane-Terminated Polyurethanes with high stregth and high elongation Construction Research & Technology GmbH (DE) 2005-10-05 EP claimed
US-20050215701-A1 Silane-terminated polyurethanes with high strength and high elongation CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) 2005-09-29 US claimed
EP-3215546-B1 LATEX COMPRISING WATER-SOLUBLE ACRYLIC MODIFIED ALKYD DISPERSION AND METHOD OF PRODUCTION THEREOF ARKEMA INC (US) 2021-06-16 EP disclosed
CN-107108817-B Latex comprising water-soluble acrylic-modified alkyd dispersion and method for producing same 阿科玛股份有限公司 2020-03-10 CN disclosed
EP-2328983-B1 BASECOAT COMPOSITIONS COMPRISING LOW MOLECULAR WEIGHT CELLULOSE MIXED ESTERS EASTMAN CHEM CO (US) 2019-08-07 EP disclosed
US-10294320-B2 Latex comprising water-soluble acrylic modified alkyd dispersion and method of production thereof ARKEMA INC. (US) 2019-05-21 US disclosed
EP-1874826-B1 COATING COMPOSITION COMPRISING A CELLULOSE MIXED ESTER EASTMAN CHEM CO (US) 2019-05-15 EP disclosed
EP-2411478-B1 REFINISH COATING COMPOSITIONS COMPRISING LOW MOLECULAR WEIGHT CELLULOSE MIXED ESTERS EASTMAN CHEM CO (US) 2018-09-19 EP disclosed
WO-2018094499-A1 WIDE TEMPERATURE RANGE POLYURETHANE ADHESIVE COMPOSITION AND ROOF SYSTEM USING SAME Soprema, Inc. (CA) 2018-05-31 WO disclosed
EP-3308901-A1 FLUX FOR LEAD-FREE SOLDER, AND LEAD-FREE SOLDER PASTE Arakawa Chemical Industries, Ltd. (JP) 2018-04-18 EP disclosed
US-5312891-A Curable polyesters EASTMAN KODAK COMPANY (US) 1994-05-17 US disclosed
US-5256759-A Curable enamel; hardness, impact strength, acid resistance, weatherproof EASTMAN KODAK COMPANY (US) 1993-10-26 US disclosed
US-5256758-A Phenolic functional polyesters; improved hardness, impact resistance and acid resistance EASTMAN KODAK COMPANY (US) 1993-10-26 US disclosed
US-5256756-A Curable solvent or water-base enamael comprising polyesters with end groups of hydroxy carboxy acid and curing agents; protective coatings for automobiles EASTMAN KODAK COMPANY (US) 1993-10-26 US disclosed
US-5256757-A Hard, impact resistant, acid corrosion resistant EASTMAN KODAK COMPANY (US) 1993-10-26 US disclosed
US-5254637-A Curable enamel with 2,2*-bisacetoacetate crosslinking agents EASTMAN KODAK COMPANY (US) 1993-10-19 US disclosed
US-5247122-A 2,2'-bisacetoacetates useful as crosslinking agents EASTMAN KODAK COMPANY (US) 1993-09-21 US disclosed
US-5245002-A Curable polyesters for automotive coatings EASTMAN KODAK COMPANY (US) 1993-09-14 US disclosed
WO-1992022598-A1 THERMOSETTING COATING COMPOSITIONS EASTMAN KODAK COMPANY (US) 1992-12-23 WO disclosed