SCHEMBL4351074

SCHEMBL4351074

C[Si](C)(O[Si](C)(C)c1cccs1)c1cccs1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 1/20 0.33
KDM4E B2RXH2 5/20 0.32
ALDH1A1 P00352 4/20 0.32
HPGD P15428 3/20 0.32
MAPT P10636 2/20 0.32
TAAR1 Q96RJ0 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
FBP1 P09467 1/20 0.32
DPP4 P27487 2/20 0.32
RPS6KB2 Q9UBS0 1/20 0.32
RAB9A P51151 4/20 0.31
NPC1 O15118 3/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
NFKB1 P19838 1/20 0.31
NFKB2 Q00653 1/20 0.31
RELA Q04206 1/20 0.31
LPL P06858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20535309 0.79 DPP4 (0.37) KDM4EALDH1A1HPGDMAPTTAAR1
SCHEMBL2341397 0.77
SCHEMBL20550992 0.77 FBP1 (0.36) TDO2KDM4EALDH1A1HPGDMAPT
SCHEMBL2290788 0.77 FBP1 (0.36) TDO2KDM4EALDH1A1HPGDMAPT
SCHEMBL2177738 0.73
SCHEMBL8983864 0.73
SCHEMBL9190818 0.73 ALDH1A1 (0.33) TDO2KDM4EALDH1A1HPGDMAPT
SCHEMBL16613151 0.71 RPS6KB2 (0.35) TDO2KDM4EALDH1A1HPGDMAPT
SCHEMBL8914799 0.71 RPS6KB2 (0.35) KDM4EALDH1A1HPGDMAPTMEN1
SCHEMBL14958040 0.71 RPS6KB2 (0.35) KDM4EALDH1A1HPGDMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7615659-B2 Preparing a palladium(0) compound by the reaction of a palladium compound with a silicone containing compound in the presence of a base; palladium(0) compounds are suitable as homogeneous catalysts, or as precursors for preparing homogeneous catalysts; storage stability UMICORE AG & CO. KG (DE) 2009-11-10 US claimed
EP-1558621-B1 METHODS FOR THE PREPARATION OF COMPOUNDS CONTAINING PALLADIUM (0) UMICORE AG & CO KG (DE) 2008-01-23 EP claimed
US-20060106239-A1 Method for the production of compounds containing palladium(0) UMICORE AG & CO. KG (DE) 2006-05-18 US claimed
US-6686495-B2 IN PRESENCE OF PALLADIUM CATALYST; USEFUL IN PRODUCING CHEMICAL INTERMEDIATES FOR PHARMACEUTICALS, OPTICAL BRIGHTENING AGENTS AND AGROCHEMICALS OMG AG & CO KG (DE) 2004-02-03 US claimed
US-20020107426-A1 Process for the preparation of mono-, bi- or poly- functional biaryls UMICORE AG & CO. KG (DE) 2002-08-08 US claimed
EP-1199292-A1 Process for the production of mono-, bi- or polyfunctional biaryls OMG AG & Co. KG (DE) 2002-04-24 EP claimed
US-20240116965-A1 ORGANOMETALLIC COMPOUNDS UMICORE AG & CO. KG (DE) 2024-04-11 US disclosed
EP-4267591-A2 ORGANOMETALLIC COMPOUNDS Umicore AG & Co. KG (DE) 2023-11-01 EP disclosed
US-20230125340-A1 (POLY)THIOPHENE-(POLY)SILOXANE BLOCK COPOLYMER AND PRODUCTION METHOD THEREOF SHIN-ETSU CHEMICAL CO., LTD. (JP) 2023-04-27 US disclosed
WO-2022136049-A2 ORGANOMETALLIC COMPOUNDS UMICORE AG & CO. KG (DE) 2022-06-30 WO disclosed
US-7615659-B2 Preparing a palladium(0) compound by the reaction of a palladium compound with a silicone containing compound in the presence of a base; palladium(0) compounds are suitable as homogeneous catalysts, or as precursors for preparing homogeneous catalysts; storage stability UMICORE AG & CO. KG (DE) 2009-11-10 US disclosed
EP-1558621-B1 METHODS FOR THE PREPARATION OF COMPOUNDS CONTAINING PALLADIUM (0) UMICORE AG & CO KG (DE) 2008-01-23 EP disclosed
US-20060106239-A1 Method for the production of compounds containing palladium(0) UMICORE AG & CO. KG (DE) 2006-05-18 US disclosed
US-6686495-B2 IN PRESENCE OF PALLADIUM CATALYST; USEFUL IN PRODUCING CHEMICAL INTERMEDIATES FOR PHARMACEUTICALS, OPTICAL BRIGHTENING AGENTS AND AGROCHEMICALS OMG AG & CO KG (DE) 2004-02-03 US disclosed
US-20020107426-A1 Process for the preparation of mono-, bi- or poly- functional biaryls UMICORE AG & CO. KG (DE) 2002-08-08 US disclosed
EP-1199292-A1 Process for the production of mono-, bi- or polyfunctional biaryls OMG AG & Co. KG (DE) 2002-04-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060106239-A1 Method for the production of compounds containing palladium(0) RPS19, SCO2, MMS19 TDO2 85/4885KDM4E 3552/4885ALDH1A1 3123/4885
US-20240116965-A1 ORGANOMETALLIC COMPOUNDS DDT, PPOX, PDCD2L TDO2 483/4885KDM4E 1447/4885ALDH1A1 2120/4885
US-20020107426-A1 Process for the preparation of mono-, bi- or poly- functional biaryls CYP4F3, CYP4F2, CYP2F1 TDO2 432/4885KDM4E 2972/4885ALDH1A1 714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.