SCHEMBL4353475

SCHEMBL4353475

CCC(COC(=O)C(C)(C)NC(=O)C(C)(C)Br)(COC(=O)C(C)(C)NC(=O)C(C)(C)Br)COC(=O)C(C)(C)NC(=O)C(C)(C)Br

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.32
MMP8 P22894 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13432087 0.81 MAPK1 (0.32) MMP8
SCHEMBL12561788 0.80 THRB (0.38) THRBMMP8
SCHEMBL16315600 0.77 PRKCA (0.31)
SCHEMBL13988989 0.75 ELANE (0.35) THRB
SCHEMBL13925054 0.74 L3MBTL1 (0.32) MMP8
SCHEMBL4632182 0.73 THRB (0.36) THRB
SCHEMBL12561792 0.72 THRB (0.40) THRB
SCHEMBL14223638 0.72 MMP8 (0.42) THRBMMP8
SCHEMBL27165259 0.72 ALDH1A1 (0.37) THRB
SCHEMBL13660322 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7557177-B2 Ring-opened azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY (US) 2009-07-07 US disclosed
EP-1569966-B1 RING-OPENED AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M INNOVATIVE PROPERTIES CO (US) 2008-05-28 EP disclosed
US-20080027210-A1 RING-OPENED AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M INNOVATIVE PROPERTIES COMPANY 2008-01-31 US disclosed
US-7294742-B2 Ring-opened azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-11-13 US disclosed
EP-1569967-B1 AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M INNOVATIVE PROPERTIES CO (US) 2006-07-19 EP disclosed
US-6992217-B2 Ring-opened azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-01-31 US disclosed
US-6969749-B2 Azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY (US) 2005-11-29 US disclosed
EP-1569967-A1 AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M Innovative Properties Company (US) 2005-09-07 EP disclosed
EP-1569966-A1 RING-OPENED AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M Innovative Properties Company (US) 2005-09-07 EP disclosed
US-20050159569-A1 Ring-opened azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY 2005-07-21 US disclosed
US-6894133-B2 Azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY (US) 2005-05-17 US disclosed
US-20050065300-A1 Azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY 2005-03-24 US disclosed
WO-2004052944-A1 RING-OPENED AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-06-24 WO disclosed
WO-2004052943-A1 AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-06-24 WO disclosed
US-20040116633-A1 Ring-opened azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY 2004-06-17 US disclosed
US-20040116616-A1 Azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY 2004-06-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050159569-A1 Ring-opened azlactone initiators for atom transfer radical polymerization TTL, TERT, AZI2 THRB 2474/4885MMP8 4712/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.