Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.48 |
| ▸ | CA6 | P23280 | 5/20 | 0.48 |
| ▸ | CA7 | P43166 | 5/20 | 0.48 |
| ▸ | CA9 | Q16790 | 5/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.48 |
| ▸ | CA2 | P00918 | 4/20 | 0.48 |
| ▸ | CA4 | P22748 | 4/20 | 0.48 |
| ▸ | CA5A | P35218 | 4/20 | 0.48 |
| ▸ | CA3 | P07451 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8214664 | 0.95 | CA12 (0.48) | CA12CA6CA7CA9CA14 | |
| SCHEMBL4350835 | 0.95 | CA12 (0.48) | CA12CA6CA7CA9CA14 | |
| SCHEMBL21409765 | 0.78 | CA12 (0.55) | CA12CA6CA7CA9CA14 | |
| SCHEMBL15782 | 0.74 | CA12 (0.50) | CA12CA6CA7CA9CA14 | |
| SCHEMBL28015356 | 0.74 | CA12 (0.50) | CA12CA6CA7CA9CA14 | |
| SCHEMBL599056 | 0.74 | CA12 (0.50) | CA12CA6CA7CA9CA14 | |
| SCHEMBL27388092 | 0.73 | CA12 (0.48) | CA12CA6CA7CA9CA14 | |
| SCHEMBL28596714 | 0.71 | CA12 (0.52) | CA12CA6CA7CA9CA14 | |
| SCHEMBL238154 | 0.71 | CA12 (0.46) | CA12CA6CA7CA9CA14 | |
| SCHEMBL687888 | 0.71 | CA12 (0.46) | CA12CA6CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8291255-A | — | — | None | — | — | JP | disclosed |
| US-7541405-B2 | Aqueous polymer dispersions | WACKER-CHEMIE GMBH (DE) | 2009-06-02 | — | — | US | disclosed |
| US-20050107520-A1 | Aqueous polymer dispersions | WACKER-CHEMIE GMBH (DE) | 2005-05-19 | — | — | US | disclosed |
| EP-1526153-A1 | Aqueous polymer dispersions | Wacker-Chemie GmbH (DE) | 2005-04-27 | — | — | EP | disclosed |
| US-6528580-B1 | Mastic, leakproofing and/or water-repelling material or film, paint or coating | RHODIA CHIMIE (FR) | 2003-03-04 | — | — | US | disclosed |
| US-6521699-B2 | Crosslinked polysiloxanes | Chimie, Rhodia (FR) | 2003-02-18 | — | — | US | disclosed |
| US-20010031818-A1 | Aqueous silicone dispersion | BLUESTAR SILICONES FRANCE. (FR) | 2001-10-18 | — | — | US | disclosed |
| US-6054523-A | CURES TO A TRANSPARENT ELASTOMER; ORGANOPOLYSILOXANE (A) HAVING CONDENSABLE GROUPS, A CONDENSATION CATALYST, ORGANOPOLYSILOXANE AT LEAST PARTIALLY SOLUBLE IN (A), A COMPOUND CONTAINING BASIC NITROGEN AND POLYVINYL ALCOHOL | WACKER-CHEMIE GMBH (DE) | 2000-04-25 | — | — | US | disclosed |
| EP-0828794-B1 | AQUEOUS DISPERSIONS OF ORGANOPOLYSILOXANES | WACKER CHEMIE GMBH (DE) | 2000-01-19 | — | — | EP | disclosed |
| US-5985994-A | RTV POLYSILOXANES FORMED BY CATALYTIC POYMERIZATION OF MONOMERS AND COPOLYMERIZATION WITH GLYCOLS | WACKER-CHEMIE GMBH (DE) | 1999-11-16 | — | — | US | disclosed |
| EP-0655475-B1 | Aqueous dispersions of organopolysiloxanes | WACKER CHEMIE GMBH (DE) | 1997-02-05 | — | — | EP | disclosed |
| EP-0419986-B1 | Aqueous dispersions of organopolysiloxanes | WACKER CHEMIE GMBH (DE) | 1996-12-18 | — | — | EP | disclosed |
| WO-1996037556-A1 | AQUEOUS DISPERSIONS OF ORGANOPOLYSILOXANES | WACKER-CHEMIE GMBH (DE) | 1996-11-28 | — | — | WO | disclosed |
| JP-H08291255-A | AQUEOUS DISPERSION OF ORGANOPOLYSILOXANE, ITS MANUFACTURE AND FINISHING AGENT OF FIBROUS MATERIAL | WACKER CHEMIE GMBH | 1996-11-05 | — | — | JP | disclosed |
| EP-0738747-A1 | Aqueous organopolysiloxane dispersions | Wacker-Chemie GmbH (DE) | 1996-10-23 | — | — | EP | disclosed |
| EP-0572006-B1 | Aqueous organopolysiloxane dispersions | WACKER CHEMIE GMBH (DE) | 1995-11-15 | — | — | EP | disclosed |
| EP-0655475-A1 | Aqueous dispersions of organopolysiloxanes | Wacker-Chemie GmbH (DE) | 1995-05-31 | — | — | EP | disclosed |
| EP-0572006-A2 | Aqueous organopolysiloxane dispersions | WACKER-CHEMIE GMBH (DE) | 1993-12-01 | — | — | EP | disclosed |
| US-5045231-A | Blend of organopolysiloxane, catalyst, and diorganosilanolate | WACKER-CHEMIE GMBH (DE) | 1991-09-03 | — | — | US | disclosed |
| EP-0419986-A2 | Aqueous dispersions of organopolysiloxanes | WACKER-CHEMIE GMBH (DE) | 1991-04-03 | — | — | EP | disclosed |