Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 5/20 | 0.48 |
| ▸ | CA2 known ✓ | P00918 | 4/20 | 0.48 |
| ▸ | CA4 known ✓ | P22748 | 4/20 | 0.48 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.43 |
| ▸ | CA6 | P23280 | 5/20 | 0.48 |
| ▸ | CA7 | P43166 | 5/20 | 0.48 |
| ▸ | CA9 | Q16790 | 5/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.48 |
| ▸ | CA5A | P35218 | 4/20 | 0.48 |
| ▸ | CA3 | P07451 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8214664 | 1.00 | CA12 (0.48) | CA12CA6CA7CA9CA14 | |
| Potassium Ion SCHEMBL4355913 | 0.95 | CA12 (0.48) | CA12CA6CA7CA9CA14 | |
| SCHEMBL21409765 | 0.78 | CA12 (0.55) | CA12CA6CA7CA9CA14 | |
| SCHEMBL15782 | 0.74 | CA12 (0.50) | CA12CA6CA7CA9CA14 | |
| SCHEMBL599056 | 0.74 | CA12 (0.50) | CA12CA6CA7CA9CA14 | |
| SCHEMBL28015356 | 0.74 | CA12 (0.50) | CA12CA6CA7CA9CA14 | |
| SCHEMBL16150345 | 0.74 | CA12 (0.71) | CA12CA6CA7CA9CA14 | |
| SCHEMBL27388092 | 0.73 | CA12 (0.48) | CA12CA6CA7CA9CA14 | |
| SCHEMBL28596714 | 0.71 | CA12 (0.52) | CA12CA6CA7CA9CA14 | |
| SCHEMBL238154 | 0.71 | CA12 (0.46) | CA12CA6CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541405-B2 | Aqueous polymer dispersions | WACKER-CHEMIE GMBH (DE) | 2009-06-02 | — | — | US | disclosed |
| US-20050107520-A1 | Aqueous polymer dispersions | WACKER-CHEMIE GMBH (DE) | 2005-05-19 | — | — | US | disclosed |
| EP-1526153-A1 | Aqueous polymer dispersions | Wacker-Chemie GmbH (DE) | 2005-04-27 | — | — | EP | disclosed |
| US-6054523-A | CURES TO A TRANSPARENT ELASTOMER; ORGANOPOLYSILOXANE (A) HAVING CONDENSABLE GROUPS, A CONDENSATION CATALYST, ORGANOPOLYSILOXANE AT LEAST PARTIALLY SOLUBLE IN (A), A COMPOUND CONTAINING BASIC NITROGEN AND POLYVINYL ALCOHOL | WACKER-CHEMIE GMBH (DE) | 2000-04-25 | — | — | US | disclosed |
| EP-0828794-B1 | AQUEOUS DISPERSIONS OF ORGANOPOLYSILOXANES | WACKER CHEMIE GMBH (DE) | 2000-01-19 | — | — | EP | disclosed |
| US-5985994-A | RTV POLYSILOXANES FORMED BY CATALYTIC POYMERIZATION OF MONOMERS AND COPOLYMERIZATION WITH GLYCOLS | WACKER-CHEMIE GMBH (DE) | 1999-11-16 | — | — | US | disclosed |
| EP-0828794-A1 | AQUEOUS DISPERSIONS OF ORGANOPOLYSILOXANES | Wacker-Chemie GmbH (DE) | 1998-03-18 | — | — | EP | disclosed |
| EP-0655475-B1 | Aqueous dispersions of organopolysiloxanes | WACKER CHEMIE GMBH (DE) | 1997-02-05 | — | — | EP | disclosed |
| WO-1996037556-A1 | AQUEOUS DISPERSIONS OF ORGANOPOLYSILOXANES | WACKER-CHEMIE GMBH (DE) | 1996-11-28 | — | — | WO | disclosed |
| EP-0738747-A1 | Aqueous organopolysiloxane dispersions | Wacker-Chemie GmbH (DE) | 1996-10-23 | — | — | EP | disclosed |
| EP-0572006-B1 | Aqueous organopolysiloxane dispersions | WACKER CHEMIE GMBH (DE) | 1995-11-15 | — | — | EP | disclosed |
| EP-0655475-A1 | Aqueous dispersions of organopolysiloxanes | Wacker-Chemie GmbH (DE) | 1995-05-31 | — | — | EP | disclosed |
| EP-0572006-A2 | Aqueous organopolysiloxane dispersions | WACKER-CHEMIE GMBH (DE) | 1993-12-01 | — | — | EP | disclosed |