Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | FASN | P49327 | 2/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355595 | 0.94 | POLB (0.54) | POLBHPGDCYP2C9FASNGRM5 | |
| SCHEMBL4533028 | 0.90 | HPGD (0.41) | POLBHPGDL3MBTL3L3MBTL1ALDH1A1 | |
| SCHEMBL4536116 | 0.89 | STAT3 (0.43) | POLBHPGDROCK2BMPR1BBMPR1A | |
| SCHEMBL4347885 | 0.88 | GPR119 (0.37) | POLBHPGDGPR119FASNGRM5 | |
| SCHEMBL4356808 | 0.88 | SETD7 (0.45) | POLBHPGDROCK2GPR119ALDH1A1 | |
| SCHEMBL13586034 | 0.87 | ABL1 (0.46) | POLBROCK2GPR119PTPN2PTPN1 | |
| SCHEMBL4538191 | 0.86 | TNKS (0.41) | ROCK2L3MBTL3L3MBTL1GPR119BMPR1B | |
| SCHEMBL4520212 | 0.86 | PTPN2 (0.47) | POLBHPGDFASNALDH1A1SMN1; SMN2 | |
| SCHEMBL4535866 | 0.86 | GPR119 (0.36) | CYP2C9GPR119SMN1; SMN2 | |
| SCHEMBL4538463 | 0.85 | NPY2R (0.39) | ROCK2CYP2C9GPR119ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150144-A1 | NEW GPR119MODULATORS | INOVACIA AB (SE) | 2009-12-17 | — | — | WO | claimed |
| WO-2009150144-A1 | NEW GPR119MODULATORS | INOVACIA AB (SE) | 2009-12-17 | — | — | WO | disclosed |