SCHEMBL43586

SCHEMBL43586

CC(Nc1nccs1)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
FDPS P14324 1/20 0.53
LMNA P02545 2/20 0.49
TSHR P16473 1/20 0.49
HSD17B10 Q99714 1/20 0.48
HTT P42858 1/20 0.47
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
FFAR2 O15552 1/20 0.46
AURKA O14965 1/20 0.45
PIM1 P11309 1/20 0.45
CDK2 P24941 1/20 0.45
GSK3B P49841 1/20 0.45
HSPA9 P38646 2/20 0.45
HSPA5 P11021 1/20 0.45
ADORA2A P29274 1/20 0.44
NR3C1 P04150 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL288965 1.00 FDPS (0.53) FDPSLMNATSHRHSD17B10HTT
SCHEMBL43587 1.00 FDPS (0.53) FDPSLMNATSHRHSD17B10HTT
SCHEMBL14940427 0.81 CTSC (0.49) LMNATSHRHSD17B10RAB9AHSPA9
SCHEMBL577833 0.77
SCHEMBL12966147 0.76 HSPA9 (0.52) FDPSLMNATSHRHTTNPC1
SCHEMBL8701148 0.76 FDPS (0.50) FDPSLMNATSHRHSD17B10HTT
SCHEMBL8701152 0.76 FDPS (0.50) FDPSLMNATSHRHSD17B10HTT
SCHEMBL4455601 0.76 FDPS (0.46) FDPSLMNATSHRHTTNPC1
SCHEMBL4469605 0.76 FDPS (0.46) FDPSLMNATSHRHTTNPC1
SCHEMBL4455593 0.76 FDPS (0.46) FDPSLMNATSHRHTTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1475 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119015394-A Sulfur-containing compound preparation, and preparation method and application thereof 上海优斐斯生物科技有限公司 2024-11-26 CN claimed
EP-3912641-B1 HYDROPHILIC DRUG-LINKER COMPOUNDS SEAGEN INC (US) 2024-11-06 EP claimed
US-20240174715-A1 PEPTIDE LIBRARIES WITH NON-CANONICAL AMINO ACIDS INDI MOLECULAR, INC. 2024-05-30 US claimed
US-11919972-B2 Peptide libraries with non-canonical amino acids REGENERON PHARMACEUTICALS, INC. (US) 2024-03-05 US claimed
US-20230355708-A1 COMPOSITIONS FOR INHIBITING VIRAL ENTRY AND METHODS USING SAME UNIV DREXEL (US) 2023-11-09 US claimed
US-20230132738-A1 HYDROPHILIC ANTIBODY-DRUG CONJUGATES SEAGEN INC (US) 2023-05-04 US claimed
US-11510959-B2 Hydrophilic antibody-drug conjugates SEAGEN INC. (US) 2022-11-29 US claimed
WO-2022072469-A1 COMPOSITIONS FOR INHIBITING VIRAL ENTRY AND METHODS USING SAME DREXEL UNIVERSITY (US) 2022-04-07 WO claimed
EP-3970801-A1 RAS INHIBITORY PEPTIDE Ichimaru Pharcos Co., Ltd. (JP) 2022-03-23 EP claimed
CN-113727991-A Ras inhibitory peptide 一丸自然美健有限公司 2021-11-30 CN claimed
US-20070021346-A1 N-terminally modified GLP-1 receptor modulators BRISTOL-MYERS SQUIBB COMPANY 2007-01-25 US claimed
US-7160705-B2 Arginine repressor deficient strain of coryneform bacterium and method for producing L-arginine AJINOMOTO CO., INC. (JP) 2007-01-09 US claimed
WO-2006127948-A2 N-TERMINALLY MODIFIED GLP-1 RECEPTOR MODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2006-11-30 WO claimed
EP-1194531-A2 CYCLIC PEPTIDOMIMETIC UROKINASE RECEPTOR ANTAGONISTS Wilex AG (DE) 2002-04-10 EP claimed
US-6232305-B1 ANTICANCER AGENTS; BONE DISORDERS; ANTIARTHRITIC AGENTS; RESPIRATORY SYSTEM DISORDERS NAEJA PHARMACEUTICAL INC. (CA) 2001-05-15 US claimed
WO-2001005811-A2 CYCLIC PEPTIDOMIMETIC UROKINASE RECEPTOR ANTAGONISTS WILEX AG (DE) 2001-01-25 WO claimed
WO-1997046553-A1 THROMBIN INHIBITORS NOVARTIS AG (CH) 1997-12-11 WO claimed
US-4393135-A GENETICALLY ENGINEERED ESCHERICHIA AJINOMOTO COMPANY INCORPORATED (JP) 1983-07-12 US claimed
US-4388405-A ESCHERICHIA INCORPORATED WITH HYBRID PLASMID AJINOMOTO COMPANY INCORPORATED (JP) 1983-06-14 US claimed
EP-0030391-A2 Method for producing L-glutamic acid by fermentation and a method for producing a new microorganism AJINOMOTO CO., INC. (JP) 1981-06-17 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021346-A1 N-terminally modified GLP-1 receptor modulators GLP1R, GIPR, IAPP FDPS 4020/4885LMNA 2525/4885TSHR 70/4885
US-11510959-B2 Hydrophilic antibody-drug conjugates CD44, FCGR1A, FCGR2A FDPS 4028/4885LMNA 3561/4885TSHR 800/4885
US-20240174715-A1 PEPTIDE LIBRARIES WITH NON-CANONICAL AMINO ACIDS ARGLU1, NGLY1, VIP FDPS 3323/4885LMNA 3601/4885TSHR 1064/4885
US-20230355708-A1 COMPOSITIONS FOR INHIBITING VIRAL ENTRY AND METHODS USING SAME GALNT1, GALNT2, LGALS1 FDPS 1389/4885LMNA 233/4885TSHR 4858/4885
US-20230132738-A1 HYDROPHILIC ANTIBODY-DRUG CONJUGATES CD44, FCGR1A, FCGR2A FDPS 4028/4885LMNA 3561/4885TSHR 800/4885
US-11919972-B2 Peptide libraries with non-canonical amino acids ARGLU1, NGLY1, VIP FDPS 3323/4885LMNA 3601/4885TSHR 1064/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.