Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | FBP1 | P09467 | 2/20 | 0.59 |
| ▸ | RXRA | P19793 | 1/20 | 0.58 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | TLR4 | O00206 | 1/20 | 0.53 |
| ▸ | TLR2 | O60603 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4307048 | 1.00 | MAPT (0.61) | MAPTFBP1RXRASOS1MAOB | |
| SCHEMBL14935499 | 0.87 | MAPT (0.69) | MAPTSOS1MAOBMEN1KMT2A | |
| SCHEMBL9978289 | 0.87 | MAPT (0.69) | MAPTSOS1MAOBMEN1KMT2A | |
| SCHEMBL11049170 | 0.87 | MAPT (0.69) | MAPTSOS1MAOBMEN1KMT2A | |
| SCHEMBL11299049 | 0.85 | MAPT (0.67) | MAPTSOS1MAOBMEN1KMT2A | |
| SCHEMBL11296000 | 0.85 | MAPT (0.67) | MAPTSOS1MAOBMEN1KMT2A | |
| SCHEMBL5440784 | 0.83 | SOS1 (0.71) | MAPTSOS1MAOBMEN1KMT2A | |
| SCHEMBL5440780 | 0.83 | SOS1 (0.71) | MAPTSOS1MAOBMEN1KMT2A | |
| SCHEMBL24492388 | 0.82 | FBP1 (0.51) | MAPTFBP1RXRATLR4TLR2 | |
| SCHEMBL28704930 | 0.82 | FBP1 (0.51) | MAPTFBP1RXRATLR4TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106117113-A | Polysubstituted carbazole, derivant and synthetic method thereof | 湘潭大学 | 2016-11-16 | — | — | CN | claimed |
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7479500-B2 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | WYETH (US) | 2009-01-20 | — | — | US | disclosed |
| US-7419986-B2 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2008-09-02 | — | — | US | disclosed |
| US-7381723-B2 | Azabicyclylmethyl derivatives of 7,8-dihydro-1,6,9,-trioxa-3-aza-cyclopenta[a]naphthalene as 5-HT1A antagonists | WYETH (US) | 2008-06-03 | — | — | US | disclosed |
| US-7335666-B2 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2008-02-26 | — | — | US | disclosed |
| US-20070004702-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2007-01-04 | — | — | US | disclosed |
| US-20060293301-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2006-12-28 | — | — | US | disclosed |
| US-7153849-B2 | Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans | WYETH (US) | 2006-12-26 | — | — | US | disclosed |
| US-20060276481-A1 | Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| US-20020183336-A1 | Azabicyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene as 5-ht1a antagonists | AMERICAN HOME PRODUCTS CORPORATION | 2002-12-05 | — | — | US | disclosed |
| US-20020183352-A1 | Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole | WYETH (US) | 2002-12-05 | — | — | US | disclosed |
| WO-2002088145-A1 | AZABICYCLYLMETHYL DERIVATIVES OF 7,8-DIHYDRO-1,6,9-TRIOXA-3-AZACYCLOPENTA[a]NAPHTHALENE AS 5-HT1A ANTAGONISTS | WYETH (US) | 2002-11-07 | — | — | WO | disclosed |
| WO-2002088146-A2 | ANTIDEPRESSANT INDOLETETRAHYDROPYRIDINE DERIVATIVES OF 2,3-DIHYDRO-7H-[1,4]DIOXINO[2,3-e]INDOLE | WYETH (US) | 2002-11-07 | — | — | WO | disclosed |
| EP-0598383-B1 | Process for the preparation of 5,6-diacetoxyindole | BRISTOL MYERS SQUIBB CO (US) | 1999-02-03 | — | — | EP | disclosed |
| US-5536865-A | Process for the preparation of 5,6-dihydroxyindole and intermediate compounds | L'OREAL (FR) | 1996-07-16 | — | — | US | disclosed |
| US-5508464-A | NITRATING OF A 4,5-DIBENZYLOXYPHENYLACETONITRILE, FOLLOWED BY DEBENZYLATION, HYDROGENATION AND CYCLIZATION | L'OREAL (FR) | 1996-04-16 | — | — | US | disclosed |
| US-5498746-A | Process for the preparation of 5,6-dihydroxyindole and intermediate compounds | L'OREAL (FR) | 1996-03-12 | — | — | US | disclosed |
| US-5410067-A | Catalytic hydrogenation; cyclization | L'OREAL (FR) | 1995-04-25 | — | — | US | disclosed |
| US-4822375-A | LIGHTFAST, WEATHER RESISTANT, NATURAL APPEARING HAIR DYES | L'OREAL (FR) | 1989-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293301-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | CRH, HTR5A, DBH | MAPT 2773/4885FBP1 3278/4885RXRA 2834/4885 |
| US-20060276481-A1 | Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans | HTR5A, CRH, TAAR5 | MAPT 2722/4885FBP1 3108/4885RXRA 3592/4885 |
| US-20020183352-A1 | Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole | TPH1, OPRD1, HTR1D | MAPT 1714/4885FBP1 1305/4885RXRA 3237/4885 |
| US-20020183336-A1 | Azabicyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene as 5-ht1a antagonists | HTR1A, HTR5A, HTR1D | MAPT 775/4885FBP1 3938/4885RXRA 2443/4885 |
| US-20070004702-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | CRH, CYP19A1, HTR5A | MAPT 3070/4885FBP1 3647/4885RXRA 3125/4885 |
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | HTR5A, OPRD1, CRH | MAPT 2292/4885FBP1 2949/4885RXRA 4097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.