Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27927354 | 1.00 | ALDH1A1 (0.41) | ALDH1A1KDM4EL3MBTL1LOXL2RAB9A | |
| SCHEMBL469111 | 1.00 | ALDH1A1 (0.41) | ALDH1A1KDM4EL3MBTL1LOXL2RAB9A | |
| SCHEMBL21866491 | 0.78 | L3MBTL1 (0.51) | ALDH1A1KDM4EL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL1270980 | 0.78 | L3MBTL1 (0.42) | ALDH1A1KDM4EL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL21866490 | 0.78 | L3MBTL1 (0.51) | ALDH1A1KDM4EL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL11885260 | 0.78 | L3MBTL1 (0.42) | ALDH1A1KDM4EL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL1270979 | 0.78 | L3MBTL1 (0.42) | ALDH1A1KDM4EL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL7970830 | 0.76 | LOXL2 (0.45) | ALDH1A1LOXL2SMN1; SMN2NPC1MAPT | |
| SCHEMBL7970832 | 0.76 | LOXL2 (0.45) | ALDH1A1LOXL2SMN1; SMN2NPC1MAPT | |
| SCHEMBL10666814 | 0.76 | RECQL (0.42) | ALDH1A1KDM4EL3MBTL1LOXL2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278306-B2 | C-met protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-02 | — | — | US | disclosed |
| US-20120065213-A1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065213-A1 | C-MET PROTEIN KINASE INHIBITORS | MET, PRKCH, MYLK | ALDH1A1 3009/4885KDM4E 1687/4885L3MBTL1 1045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.