Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.46 |
| ▸ | CDK9 | P50750 | 4/20 | 0.46 |
| ▸ | QDPR | P09417 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL614978 | 0.76 | CCNT1 (0.57) | CCNT1CDK9QDPRHTR2CALDH1A1 | |
| SCHEMBL31348179 | 0.76 | CCNT1 (0.57) | CCNT1CDK9QDPRHTR2CALDH1A1 | |
| SCHEMBL16802138 | 0.75 | HTR2C (0.57) | CCNT1CDK9QDPRHTR2CALDH1A1 | |
| Hydrochloric Acid SCHEMBL13584450 | 0.74 | HTR2C (0.54) | QDPRHTR2CALDH1A1KDM4EMAPT | |
| SCHEMBL4144078 | 0.73 | SUV39H2 (0.39) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6816705 | 0.72 | MET (0.45) | CCNT1CDK9QDPRHTR2CALDH1A1 | |
| SCHEMBL10903369 | 0.72 | CCNT1 (0.43) | CCNT1CDK9QDPRHTR2CALDH1A1 | |
| SCHEMBL10903364 | 0.72 | QDPR (0.49) | CCNT1CDK9QDPRALDH1A1KDM4E | |
| SCHEMBL11740786 | 0.70 | KDM4E (0.49) | ALDH1A1KDM4EMAPTHSD17B10MEN1 | |
| SCHEMBL10557861 | 0.70 | HTR2A (0.65) | CCNT1CDK9QDPRHTR2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7479500-B2 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | WYETH (US) | 2009-01-20 | — | — | US | disclosed |
| US-7479500-B2 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | WYETH (US) | 2009-01-20 | — | — | US | disclosed |
| US-7479500-B2 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | WYETH (US) | 2009-01-20 | — | — | US | disclosed |
| US-20050228009-A1 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | WYETH (US) | 2005-10-13 | — | — | US | disclosed |
| US-6939877-B2 | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2005-09-06 | — | — | US | disclosed |
| EP-1537120-A1 | ANTIDEPRESSANT PIPERIDINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | Wyeth, A Corporation of the State of Delaware (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040147523-A1 | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans | WYETH | 2004-07-29 | — | — | US | disclosed |
| WO-2004024733-A1 | ANTIDEPRESSANT PIPERIDINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228009-A1 | Antidepressant piperidine derivatives of heterocyclefused benzodioxans | HTR5A, OPRD1, DRD2 | CCNT1 1490/4885CDK9 428/4885QDPR 551/4885 |
| US-20040147523-A1 | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans | HTR5A, OPRD1, CRH | CCNT1 1970/4885CDK9 390/4885QDPR 619/4885 |
| US-20090042895-A1 | Antidepressant Piperidine Derivatives of Heterocycle-Fused Benzodioxans | HTR5A, OPRD1, CRH | CCNT1 2021/4885CDK9 361/4885QDPR 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.