Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.47 |
| ▸ | MMP9 | P14780 | 5/20 | 0.47 |
| ▸ | MMP7 | P09237 | 2/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 4/20 | 0.42 |
| ▸ | MMP14 | P50281 | 4/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.41 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372697 | 0.87 | MMP2 (0.46) | MMP2MMP9MMP7HPGDSMMP1 | |
| SCHEMBL1798298 | 0.83 | ADAM17 (0.41) | MMP2MMP9MMP7HPGDSMMP1 | |
| SCHEMBL4374878 | 0.82 | MMP7 (0.41) | MMP2MMP9MMP7HPGDSMMP1 | |
| SCHEMBL1798732 | 0.82 | ADAMTS7 (0.44) | MMP2MMP9MMP7HPGDSMMP1 | |
| SCHEMBL1798731 | 0.82 | ADAMTS7 (0.44) | MMP2MMP9MMP7HPGDSMMP1 | |
| SCHEMBL1800984 | 0.81 | ADAM17 (0.40) | MMP2MMP9MMP7MMP1MMP14 | |
| SCHEMBL4377641 | 0.80 | MMP2 (0.40) | MMP2MMP9MMP7HPGDSMMP1 | |
| SCHEMBL11989266 | 0.79 | SIRT5 (0.41) | MMP2MMP9MMP7HPGDSMMP1 | |
| SCHEMBL1802616 | 0.79 | SIRT5 (0.41) | MMP2MMP9MMP7HPGDSMMP1 | |
| SCHEMBL1798434 | 0.79 | ADAM17 (0.43) | MMP2MMP9MMP7MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |