Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 8/20 | 0.41 |
| ▸ | BMP1 | P13497 | 3/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.39 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 4/20 | 0.37 |
| ▸ | MMP9 | P14780 | 4/20 | 0.37 |
| ▸ | MMP14 | P50281 | 3/20 | 0.37 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.37 |
| ▸ | ADAM8 | P78325 | 2/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11989266 | 1.00 | SIRT5 (0.41) | SIRT5BMP1SIRT2HPGDSMMP1 | |
| SCHEMBL1800984 | 0.89 | ADAM17 (0.40) | BMP1MMP1ADAM17ADAMTS4ADAMTS1 | |
| SCHEMBL1798298 | 0.88 | ADAM17 (0.41) | BMP1HPGDSMMP1ADAM17ADAMTS4 | |
| SCHEMBL1798434 | 0.87 | ADAM17 (0.43) | BMP1MMP1ADAM17ADAMTS4ADAMTS1 | |
| SCHEMBL4370883 | 0.85 | WNT3A (0.37) | MMP1ADAM17ADAMTS4ADAMTS1ADAMTS7 | |
| SCHEMBL3871098 | 0.79 | HPGDS (0.37) | SIRT5SIRT2HPGDSMMP2MMP9 | |
| SCHEMBL1800811 | 0.79 | BMP1 (0.51) | BMP1MMP1ADAM17ADAMTS4ADAMTS1 | |
| SCHEMBL4372679 | 0.79 | MMP2 (0.47) | HPGDSMMP1ADAM17ADAMTS4ADAMTS1 | |
| SCHEMBL4372697 | 0.79 | MMP2 (0.46) | BMP1HPGDSMMP1ADAM17ADAMTS4 | |
| SCHEMBL7174227 | 0.76 | CA2 (0.34) | HPGDSMMP1ADAM17ADAMTS4ADAMTS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| US-20090143386-A1 | Human adam-10 inhibitors | EXELIXIS, INC. | 2009-06-04 | — | — | US | claimed |
| US-8247451-B2 | ADAM10 and its uses related to infection | VANDERBILT UNIVERSITY (US) | 2012-08-21 | — | — | US | disclosed |
| US-7951972-B2 | Human adam-10 inhibitors | EXELIXIS, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-20090220514-A1 | ADAM10 and its Uses Related to Infection | VANDERBILT UNIVERSITY | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090220514-A1 | ADAM10 and its Uses Related to Infection | ADAM10, ADAM12, ADAM17 | SIRT5 2105/4885BMP1 1863/4885SIRT2 3120/4885 |
| US-20090143386-A1 | Human adam-10 inhibitors | ADAM10, ADAM12, CASP10 | SIRT5 1543/4885BMP1 2810/4885SIRT2 1312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.