Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 4/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP7 | P09237 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 5/20 | 0.32 |
| ▸ | LGMN | Q99538 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.31 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3871098 | 0.88 | HPGDS (0.37) | MMP2MMP9HPGDSF2CTSL | |
| SCHEMBL4374530 | 0.88 | MMP2 (0.36) | MMP2MMP9HPGDSMMP1MMP3 | |
| SCHEMBL4369622 | 0.86 | MMP2 (0.35) | MMP2MMP9HPGDSWNT3AMMP1 | |
| SCHEMBL1800259 | 0.85 | HPGDS (0.39) | MMP2MMP9HPGDSWNT3AMMP1 | |
| SCHEMBL1797052 | 0.83 | F2 (0.37) | WNT3AF2F10 | |
| SCHEMBL4372679 | 0.80 | MMP2 (0.47) | MMP2MMP9HPGDSMMP1MMP7 | |
| SCHEMBL7174227 | 0.79 | CA2 (0.34) | MMP2MMP9HPGDSWNT3AMMP1 | |
| SCHEMBL1798298 | 0.79 | ADAM17 (0.41) | MMP2MMP9HPGDSMMP1MMP7 | |
| SCHEMBL4374481 | 0.76 | MMP2 (0.50) | MMP2MMP9MMP1MMP3MMP7 | |
| SCHEMBL1800984 | 0.74 | ADAM17 (0.40) | MMP2MMP9MMP1MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |