Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 15/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 15/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370947 | 0.88 | OPRM1 (0.40) | OPRM1OPRD1OPRK1HRH3MLNR | |
| SCHEMBL1798242 | 0.77 | MMP2 (0.42) | OPRM1OPRD1OPRK1MLNRCYP2D6 | |
| SCHEMBL1800017 | 0.73 | MMP2 (0.44) | HTT | |
| SCHEMBL1798723 | 0.67 | ADAM17 (0.49) | — | |
| SCHEMBL4375889 | 0.65 | MAPK8 (0.35) | ALDH1A1HTTNPSR1 | |
| SCHEMBL14878471 | 0.64 | OPRM1 (0.41) | OPRM1OPRD1OPRK1HRH3 | |
| SCHEMBL14380137 | 0.64 | ALDH1A1 (0.57) | OPRM1OPRD1OPRK1HRH3MLNR | |
| SCHEMBL13604602 | 0.63 | OPRM1 (0.46) | OPRM1OPRD1OPRK1HRH3 | |
| SCHEMBL12653312 | 0.63 | OPRM1 (0.46) | OPRM1OPRD1OPRK1HRH3MLNR | |
| SCHEMBL778932 | 0.62 | NPC1 (0.49) | OPRM1OPRD1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1461313-B1 | HUMAN ADAM-10 INHIBITORS | EXELIXIS INC (US) | 2009-08-05 | — | — | EP | disclosed |